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An efficient cycle of model-prediction to user-validation for expediting intracortical brain-computer interface design

Award Number: R01NS109257
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2019
PERIOD OF PERFORMANCE END DATE: 05/31/2031

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An efficient cycle of model-prediction to user-validation for expediting intracortical brain-computer interface design - PROJECT SUMMARY Intracortical brain-computer interfaces (iBCI) have the potential to give people living with paralysis control over digital or physical assistive devices, thereby restoring some of their independence. However, “decoding” neural activity into usable commands is challenging, in part, due to the limited number of volunteers to test designs. We circumvent the volunteer shortage is as follows: First, we use a noninvasive, human-in-the-loop iBCI model developed in our prior work to evaluate many decoder variations with statistically rigorous subject cohorts, then second, we test the most promising versions in BrainGate clinical trial volunteers for validation. This will create a very efficient model to use-case validation cycle to expedite the decoder design process. In our prior work we created a new type of cursor control decoder that maps neural activity into just a few possible velocity selections rather than permitting any 2D cursor velocity, as virtually all prior iBCI decoders do, which substantially improved performance in both the iBCI model subjects and in a monkey-controlled iBCI validation. Our first goal, therefore, is to isolate the feature of “selection-based” decoding most responsible for the improvement so it can be proliferated to other iBCI designs. We using the iBCI model the test each feature, then with BrainGate clinical trial volunteers, we will compare the best performing selection-based decoders with their current decoders to validate that the model results translate to the iBCI use. Our second goal is to design an assessment tool that will allow us to pool as much data as possible across human iBCI users from different studies to maximize use of this scarce data and improve the rigor of the decoder design process. The tool will scale difficulty dynamically to maximize the range of decoders which it will have the sensitivity to distinguish between (from simple linear iBCI decoders to able-bodied computer mouse use), to capture the most amount of data and allow comparisons with clinically relevant uses. We will design and parameterize the tool using the iBCI model, then use the result to assess performance in BrainGate iBCI users. Our third goal is to understand how design principles differ between iBCI control of massless 2D cursors and physical robots. Though cursors are controlled via velocity commands, different assistive robots may perform better under different command modes. We will use the iBCI model to test a variety of command modes (endpoint position, joint angle velocity, motor torque, etc.) for control of two assistive robots: a table-mounted robotic arm and a free moving floor robot with gripper. Once we determine which is most effective, we will validate the results in BrainGate iBCI volunteers. Our final goal is to extend the scope of the iBCI model. In our prior work we designed the simulator to model tasks with ≤ 8 continuous degrees of freedom; however more recently iBCI studies have focused on abstract tasks with many discrete selections, like letter or word choices for communication. Using data from BrainGate partners, we will extend the iBCI model to accurately capture this domain so we may extend the applicability of the model to expedite progress in the composition area as well.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $562,234 )
2026	2026	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	6/23/2026	COMPETING CONTINUATION	$562,234
														Subtotal = $562,234

Issue Date FY: 2025 ( Subtotal = -$2 )
2025	2023	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	004	5	12/13/2024	NON-COMPETING CONTINUATION	-$535,354
2025	2023	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	6	12/12/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$111,941
2025	2023	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	5	12/13/2024	NON-COMPETING CONTINUATION	$535,354
2025	2023	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	12/11/2024	NON-COMPETING CONTINUATION	-$111,943
2025	2023	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	5	12/13/2024	NON-COMPETING CONTINUATION	-$535,354
2025	2023	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	005	5	12/13/2024	NON-COMPETING CONTINUATION	$535,354
2025	2023	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	006	5	12/13/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = -$2

Issue Date FY: 2024 ( Subtotal = -$535,354 )
2024	2023	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	7/25/2024	NON-COMPETING CONTINUATION	-$254,534
2024	2022	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	7/25/2024	NON-COMPETING CONTINUATION	-$280,820
														Subtotal = -$535,354

Issue Date FY: 2023 ( Subtotal = $254,534 )
2023	2023	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	5/22/2023	NON-COMPETING CONTINUATION	$254,534
														Subtotal = $254,534

Issue Date FY: 2022 ( Subtotal = $308,752 )
2022	2022	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	6/9/2022	NON-COMPETING CONTINUATION	$308,752
														Subtotal = $308,752

Issue Date FY: 2021 ( Subtotal = $334,572 )
2021	2021	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	6/10/2021	NON-COMPETING CONTINUATION	$334,572
														Subtotal = $334,572

Issue Date FY: 2020 ( Subtotal = $327,626 )
2020	2020	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	6/5/2020	NON-COMPETING CONTINUATION	$327,626
														Subtotal = $327,626

Issue Date FY: 2019 ( Subtotal = $367,007 )
2019	2019	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	8/14/2019	NEW	$367,007
														Subtotal = $367,007

Grand Total All Awards = $1,619,369

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An efficient cycle of model-prediction to user-validation for expediting intracortical brain-computer interface design

Award Number: R01NS109257

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2019

PERIOD OF PERFORMANCE END DATE: 05/31/2031

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