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Role of interneurons in brain tissue oxygen regulation

Award Number: R01NS107383
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2018
PERIOD OF PERFORMANCE END DATE: 12/31/2029

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Role of interneurons in brain tissue oxygen regulation - The regulation of oxygen in brain tissue is a fundamental question in neuroscience and medicine, as it is crucial for maintaining optimal brain function. GABAergic interneurons, which provide inhibitory signals in the cerebral cortex, have been found to not only connect with other neurons but also with arterioles, enabling them to control network activity and vasomotion to regulate blood delivery within the brain. However, the specific mechanisms by which interneurons contribute to local oxygen homeostasis remain unclear. Building upon our published and preliminary data, we propose that interneurons, utilizing their dual neurotransmission function, play a primary role in regulating both brain tissue oxygen (PO2) levels and BOLD fMRI responses. To investigate this hypothesis, we have designed a comprehensive study comprising three specific aims. In Specific Aim 1, we will determine the role of GABA in the magnitude and direction of PO2 responses. Specific Aim 2 focuses on investigating the role of the dual neurotransmission system in PO2 responses. In Specific Aim 3, we will investigate how the absence of excitatory activity in pyramidal cells affects oxygen responses. The proposed studies on neuronal regulation of oxygen in brain tissue hold broad implications for understanding the relationship between neuronal activity and oxygenation. They have significant relevance to both healthy brain functioning and conditions involving vascular dysfunction. By elucidating the mechanisms underlying brain tissue oxygen regulation, these investigations will also offer insights into epileptic and sub-convulsive states. Additionally, improving our fundamental understanding of neuronal tissue oxygen regulation has the potential to enhance neuroimaging methods, such as fMRI, leading to more accurate interpretations of brain activity and function.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $410,000 )
2026	2026	ENDEAVOR HEALTH CLINICAL OPERATIONS	1301 CENTRAL ST	EVANSTON	IL	60201	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	12/16/2025	NON-COMPETING CONTINUATION	$369,000
2026	2026	ENDEAVOR HEALTH CLINICAL OPERATIONS	1301 CENTRAL ST	EVANSTON	IL	60201	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	7	2/28/2026	NON-COMPETING CONTINUATION	$41,000
														Subtotal = $410,000

Issue Date FY: 2025 ( Subtotal = $408,592 )
2025	2025	ENDEAVOR HEALTH CLINICAL OPERATIONS	1301 CENTRAL ST	EVANSTON	IL	60201	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	6	1/16/2025	COMPETING CONTINUATION	$410,000
2025	2022	ENDEAVOR HEALTH CLINICAL OPERATIONS	1301 CENTRAL ST	EVANSTON	IL	60201	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	10/22/2024	NON-COMPETING CONTINUATION	-$1,408
														Subtotal = $408,592

Issue Date FY: 2022 ( Subtotal = $310,676 )
2022	2022	NORTHSHORE UNIVERSITY HEALTHSYSTEM	1301 CENTRAL ST	EVANSTON	IL	60201	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	6/16/2022	NON-COMPETING CONTINUATION	$310,676
														Subtotal = $310,676

Issue Date FY: 2021 ( Subtotal = $311,586 )
2021	2021	NORTHSHORE UNIVERSITY HEALTHSYSTEM	1301 CENTRAL ST	EVANSTON	IL	60201	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	5/24/2021	NON-COMPETING CONTINUATION	$311,586
														Subtotal = $311,586

Issue Date FY: 2020 ( Subtotal = $312,467 )
2020	2020	NORTHSHORE UNIVERSITY HEALTHSYSTEM	1301 CENTRAL ST	EVANSTON	IL	60201	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	6/26/2020	NON-COMPETING CONTINUATION	$312,467
														Subtotal = $312,467

Issue Date FY: 2019 ( Subtotal = $313,324 )
2019	2019	NORTHSHORE UNIVERSITY HEALTHSYSTEM	1301 CENTRAL ST	EVANSTON	IL	60201	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	6/11/2019	NON-COMPETING CONTINUATION	$313,324
														Subtotal = $313,324

Issue Date FY: 2018 ( Subtotal = $326,521 )
2018	2018	NORTHSHORE UNIVERSITY HEALTHSYSTEM	1301 CENTRAL ST	EVANSTON	IL	60201	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	7/27/2018	NEW	$326,521
														Subtotal = $326,521

Grand Total All Awards = $2,393,166

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Role of interneurons in brain tissue oxygen regulation

Award Number: R01NS107383

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2018

PERIOD OF PERFORMANCE END DATE: 12/31/2029

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