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Neurophysiologically-informed Design of Flexible, 2-learner Brain-Machine Interfaces for Robust and Skillful Performance

Award Number: R01NS106094
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2018
PERIOD OF PERFORMANCE END DATE: 08/31/2023

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Neurophysiologically-informed Design of Flexible, 2-learner Brain-Machine Interfaces for Robust and Skillful Performance - PROJECT SUMMARY This proposal aims to elucidate the computational and neural basis of neuroprosthetic skill learning by leveraging recent advances in the science and engineering of closed-loop brain-machine interfacing. The outcome of the proposed work has the potential to guide the development of the next generation of neurophysiologically-informed, cortically-controlled neuroprosthetic systems for patients with neurological disorders. State-of-the-art brain-machine interfaces (BMIs) leverage machine learning to rapidly calibrate to the neural activity of individuals, but performance also benefits from subjects learning to reliably produce desired neural activity patterns. The basic science and engineering principles of designing such a “2-learner BMI” in which the brain and machine synergistically learn are not well understood. Hence, this proposal aims to investigate how the brain learns when the machine undergoes different degrees of learning, how different degrees of brain learning affect long-term BMI performance, robustness, and generalization, and how these principles can guide the design of a 2-learner BMI system which facilitates brain learning. The proposal is structured in three aims: 1) To study the impact of decoder adaptation on the development of neural encoding models underlying neuroprosthetic skill; 2) To Study how decoder adaptation and resultant neural encoding model influences BMI performance with perturbations (robustness) and BMI performance on unpracticed tasks (generalization); and 3) Design and validation of the next-generation Flexible 2-Learner Decoder architecture. The analyses and experiments proposed in these aims will leverage the fundamental knowledge gained about how the brain learns and acquires neuroprosthetic skills into the neurophysiologically-informed design of robust and high-performance closed-loop motor neuroprosthetics that generalize to new tasks.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$123 )
2024	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	3/14/2024	NON-COMPETING CONTINUATION	-$123
														Subtotal = -$123

Issue Date FY: 2022 ( Subtotal = $343,378 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	3/25/2022	NON-COMPETING CONTINUATION	$343,378
														Subtotal = $343,378

Issue Date FY: 2021 ( Subtotal = $343,378 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	3/1/2021	NON-COMPETING CONTINUATION	$343,378
														Subtotal = $343,378

Issue Date FY: 2020 ( Subtotal = $343,378 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	2/24/2020	NON-COMPETING CONTINUATION	$343,378
														Subtotal = $343,378

Issue Date FY: 2019 ( Subtotal = $343,378 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	3/8/2019	NON-COMPETING CONTINUATION	$343,378
														Subtotal = $343,378

Issue Date FY: 2018 ( Subtotal = $343,378 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	2/23/2018	NEW	$343,378
														Subtotal = $343,378

Grand Total All Awards = $1,716,767

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Neurophysiologically-informed Design of Flexible, 2-learner Brain-Machine Interfaces for Robust and Skillful Performance

Award Number: R01NS106094

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2018

PERIOD OF PERFORMANCE END DATE: 08/31/2023

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