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A Nanoelectronic Strategy for Reliable, Large-scale Chronic Neural Recording

Award Number: R01NS102917
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2017
PERIOD OF PERFORMANCE END DATE: 04/30/2029

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A Nanoelectronic Strategy for Reliable, Large-scale Chronic Neural Recording - Abstract The brain functions that give rise to perception, cognition and behavior are generated by complex, distributed neural circuits whose activity patterns change on the timescale of milliseconds. The dynamics of these activity patterns reflect complex interactions among many neurons, evolve with experience and change in disease. Technologies that have the potential to help us understand that evolving complexity must therefore be able to record and stimulate at cellular-spatial and millisecond-temporal resolutions, flexibly distribute large numbers of recording sites to target both local and distributed circuits, and importantly, minimally disrupt the integrity of neural tissue and maintain functionality stably for long time periods. Neural electrodes have been a primary tool for these purposes and contributed tremendously to fundamental and clinical neuroscience. However, conventional neural electrodes are limited by the inability to consistently record high quality neural signals over both the short and long terms. In time scales as short as hours substantial recording condition changes often occur due to the micro-movements of the implanted electrodes relative to the brain tissue. Over weeks to months, deterioration in recording efficacy and fidelity are caused by sustained foreign body reactions at the tissue-probe interface including neural degradation, reoccurring leakage in capillaries and glial scar tissue formation. The PI’s laboratory has previously created the ultraflexible neural electrodes. These devices are as thin as only 1 µm (up to 5 – 8 for large animal brains) and are therefore extremely flexible, allowing for seamless tissue integration with no observable neuronal degeneration and glial scaring. The overall objective of this project is to develop an integrated, fully implanted and untethered system to democratize large-scale, chronic stable neural recording. Empowered by this system, we will perform a comprehensive characterization on chronic neural recordings tracking the same neuron populations, and delineate stable and drifting features. Our aims are: AIM-1. To develop high-density NETs and their integration with implantable electronics. AIM-2. Develop integrated circuits (IC) and electronics for distributed and untethered neural recording. AIM-3. To establish a standard data set that characterizes endogenous changes in neural recordings. Importantly, the approach is innovative, because the technology we will develop is expected to be the most biocompatible large-scale neural recording and stimulation tool in neuroscience, and can enable new, very high- density recording studies and lead to fundamental discoveries.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $583,788 )
2025	2025	WILLIAM MARSH RICE UNIVERSITY	6100 MAIN ST	HOUSTON	TX	77005	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	6/18/2025	NON-COMPETING CONTINUATION	$583,788
														Subtotal = $583,788

Issue Date FY: 2024 ( Subtotal = $562,097 )
2024	2024	WILLIAM MARSH RICE UNIVERSITY	6100 MAIN ST	HOUSTON	TX	77005	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	6	4/23/2024	COMPETING CONTINUATION	$596,541
2024	2022	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	4/5/2024	NON-COMPETING CONTINUATION	-$34,444
														Subtotal = $562,097

Issue Date FY: 2022 ( Subtotal = $342,344 )
2022	2022	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	4/27/2022	NON-COMPETING CONTINUATION	$342,344
														Subtotal = $342,344

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR MN 13	AUSTIN	TX	78712	TRAVIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	8/4/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $342,344 )
2020	2020	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR MN 13	AUSTIN	TX	78712	TRAVIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	004	4	9/8/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$427,044
2020	2020	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR MN 13	AUSTIN	TX	78712	TRAVIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	5/1/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$342,344
2020	2019	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR MN 13	AUSTIN	TX	78712	TRAVIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	4/30/2020	NON-COMPETING CONTINUATION	$0
2020	2019	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR MN 13	AUSTIN	TX	78712	TRAVIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	3	9/8/2020	NON-COMPETING CONTINUATION	-$342,344
2020	2018	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR MN 13	AUSTIN	TX	78712	TRAVIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	2	9/8/2020	NON-COMPETING CONTINUATION	-$84,700
														Subtotal = $342,344

Issue Date FY: 2019 ( Subtotal = $342,344 )
2019	2019	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	5/10/2019	NON-COMPETING CONTINUATION	$342,344
														Subtotal = $342,344

Issue Date FY: 2018 ( Subtotal = $342,344 )
2018	2018	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	5/25/2018	NON-COMPETING CONTINUATION	$342,344
														Subtotal = $342,344

Issue Date FY: 2017 ( Subtotal = $342,344 )
2017	2017	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	6/28/2017	NEW	$342,344
														Subtotal = $342,344

Grand Total All Awards = $2,857,605

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A Nanoelectronic Strategy for Reliable, Large-scale Chronic Neural Recording

Award Number: R01NS102917

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2017

PERIOD OF PERFORMANCE END DATE: 04/30/2029

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