Thursday, April 25, 2024 4/25/2024

Subcortical auditory processing in sports-related concussions and contact/collision sports

Award Number: R01NS102500
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

Abstract Because diagnostic criteria of concussion rely upon self-reporting—which may be unreliable in a recently concussed individual—the goal of this project is to identify a neural marker of concussion that does not require effort from the patient. Concussion adversely affects many domains and there is strong reason to believe, and preliminary data to support, that neural processing in the auditory system is negatively influenced by sports- related concussion. By using an objective electrophysiological measure of auditory processing, this work has strong potential to broaden the understanding of concussion's effect on sensory processing and to eliminate a major pitfall in diagnosis and management of concussion. This proposal uses a novel approach to understand the impact of head injury on sensory processing: the frequency-following response (FFR) to speech. The central hypothesis is this objective neurophysiological measure of auditory processing serves as a marker of disruptions to central nervous system function following concussion. In collaboration with Northwestern University Athletics, this is a prospective, longitudinal study of concussion and prolonged participation in contact/collision sports that follows ~500 student-athletes annually (~875 total) within and across sports seasons. In a typical year up to 15% of student-athletes are diagnosed with a concussion by a sports medicine physician. This provides a potent opportunity to investigate the impact of concussion on auditory processing in both the short-term (immediately after injury) and long-term (after a one- to four-year college athletic career). In the large group of non-concussed athletes, this project will establish whether, as hypothesized, auditory processing is more compromised over time in individuals participating in contact/collision sports. This project can elucidate the physiological mechanisms by which concussions and long-term participation in contact sports disrupt the central nervous system. The FFR will provide fine-grained insight into the nature of the physiological imprint of concussion. The longitudinal design in a large cohort provides powerful within- and between-subject controls for tracking head injuries and risk of injury based on sport in the short- and long-term stages, and opportunities for within-study replications. If successful, the FFR could one day serve as a fast, objective, and scalable clinical adjunct to assist in concussion diagnosis and management by indicating an individual's auditory processing profile following one or more concussions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	6/15/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $538,895 )
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	6/22/2022	NON-COMPETING CONTINUATION	$53,892
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	3/7/2022	NON-COMPETING CONTINUATION	$485,003
														Subtotal = $538,895

Issue Date FY: 2021 ( Subtotal = $555,515 )
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	2/13/2021	NON-COMPETING CONTINUATION	$555,515
														Subtotal = $555,515

Issue Date FY: 2020 ( Subtotal = $523,939 )
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	2/24/2020	NON-COMPETING CONTINUATION	$523,939
														Subtotal = $523,939

Issue Date FY: 2019 ( Subtotal = $558,869 )
2019	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST EVANSTON	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	2/27/2019	NON-COMPETING CONTINUATION	$558,869
														Subtotal = $558,869

Issue Date FY: 2018 ( Subtotal = $598,997 )
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST EVANSTON	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	2/21/2018	NEW	$598,997
														Subtotal = $598,997

Grand Total All Awards = $2,776,215

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Subcortical auditory processing in sports-related concussions and contact/collision sports

Award Number: R01NS102500

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer