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Frontal midline delta/theta rhythms and cognitive control in PD

Award Number: R01NS100849
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/25/2017
PERIOD OF PERFORMANCE END DATE: 12/31/2029

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Frontal midline delta/theta rhythms and cognitive control in PD - Abstract Cognitive symptoms of Parkinson’s disease (PD) include deficits in attention, working memory, and reasoning. These deficits affect up to 80% of PD patients and lead to mild cognitive impairment (PD-MCI) and dementia in PD (PDD). There is a critical need to better understand cognitive impairment in PD to develop new targeted treatments. Our long-term goal is to define the mechanisms of PD-related cognitive impairment. PD involves diverse processes such as dopamine and acetylcholine dysfunction, synuclein aggregation, and genetic factors. During the past funding period, we linked PD-related cognitive impairment to dysfunction in frontal midline delta (1–4 Hz) and theta (5–7 Hz) rhythms, which our work has established as a marker of cognitive control. However, it is unknown why PD patients have deficits in these low-frequency brain rhythms. Our preliminary magnetic resonance imaging (MEG) and magnetoencephalography (MRI) implicate the anterior midcingulate cortex (aMCC) as a potential source of frontal midline delta/theta rhythms. In the next funding period, our objective is to determine the mechanisms and predictive power of delta/theta rhythms in PD, which will help to better understand the pathophysiology of PD-related cognitive impairment. Collaboration between the University of New Mexico (UNM) and University of Iowa (UI) that will bring together MEG, MRI, longitudinal EEG, and adaptive subthalamic (STN) deep-brain stimulation (DBS). We will test the overall hypothesis that frontal midline delta/theta dysfunction contributes to cognitive impairments in PD. In Aim 1, we will determine the structural basis for delta/theta rhythm deficits in PD. In Aim 2, we will determine the predictive power of delta/theta rhythm deficits in PD. In Aim 3, we will determine how tuned low-frequency STN DBS impacts cortical activity and cognition. Our results will have relevance for basic-science knowledge of the fundamental pathophysiology of cognitive impairment in PD and related dementias. Because this proposal will study patients with PDD, our findings are directly relevant to Alzheimer’s-related dementias (ADRD).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $700,136 )
2026	2026	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	2/23/2026	NON-COMPETING CONTINUATION	$700,136
														Subtotal = $700,136

Issue Date FY: 2025 ( Subtotal = $727,615 )
2025	2025	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	2/21/2025	COMPETING CONTINUATION	$727,615
2025	2025	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	6	5/9/2025	COMPETING CONTINUATION	$0
														Subtotal = $727,615

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	2/21/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $429,127 )
2021	2021	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	6/28/2021	NON-COMPETING CONTINUATION	$429,127
														Subtotal = $429,127

Issue Date FY: 2020 ( Subtotal = $429,127 )
2020	2020	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	6/9/2020	NON-COMPETING CONTINUATION	$429,127
														Subtotal = $429,127

Issue Date FY: 2019 ( Subtotal = $429,127 )
2019	2019	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	6/20/2019	NON-COMPETING CONTINUATION	$429,127
														Subtotal = $429,127

Issue Date FY: 2018 ( Subtotal = $442,145 )
2018	2018	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	7/5/2018	NON-COMPETING CONTINUATION	$77,376
2018	2018	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	6/22/2018	NON-COMPETING CONTINUATION	$364,769
														Subtotal = $442,145

Issue Date FY: 2017 ( Subtotal = $403,257 )
2017	2017	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/22/2017	NEW	$403,257
														Subtotal = $403,257

Grand Total All Awards = $3,560,534

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Frontal midline delta/theta rhythms and cognitive control in PD

Award Number: R01NS100849

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/25/2017

PERIOD OF PERFORMANCE END DATE: 12/31/2029

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