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A Functional Taxonomy of Cortical Astrocytes

Award Number: R01NS099254
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/2016
PERIOD OF PERFORMANCE END DATE: 11/30/2026

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A Functional Taxonomy of Cortical Astrocytes - PROJECT SUMMARY/ABSTRACT Recent work has solidified the concept that astrocytes are critical circuit components that regulate neuronal activity, particularly synchronous types of activity. However, it remains unclear how astrocytes encode and integrate neuronal circuit signals to mediate this neuronal synchronization. Moreover, the extent to which single astrocytes function as individual computational units or operate as a syncytial network is not well understood. In the proposed research, we aim to address these gaps in knowledge by uncovering both the mechanisms by which neuronal signals are differentially transmitted to astrocytic networks, and those by which astrocytes feedback to neuronal networks. We will focus on the two major neurotransmitters in the cerebral cortex (glutamate and GABA) and one essential neuromodulator, norepinephrine (NE), since astrocytes express abundant cell-surface, G-protein coupled receptors that are activated by all three of these neuron- derived signals. We will use both ex vivo cortical slices and in vivo mouse models, and apply optical, electrophysiological, chemogenetic, and genetic techniques to test astrocytic integration into these signaling systems. Our goals are three-fold: We will determine 1) the mechanisms by which single astrocytes respond to subcellular activation of glutamate, GABA, and NE, and how those dynamics shape an astrocytic output, 2) the spatiotemporal effects on local neuronal and astrocytic networks of these three neurotransmitters/neuromodulators, and 3) the mechanisms by which astrocytes transmit cortex-wide signals to neurons. Thus, in each of the three aims, we will probe similar mechanistic questions at progressively wider neurobiological scales.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $399,503 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	10	12/22/2025	NON-COMPETING CONTINUATION	$359,553
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	10	3/3/2026	NON-COMPETING CONTINUATION	$39,950
														Subtotal = $399,503

Issue Date FY: 2025 ( Subtotal = $399,503 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	11/8/2024	NON-COMPETING CONTINUATION	$359,553
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	9	8/7/2025	NON-COMPETING CONTINUATION	$39,950
														Subtotal = $399,503

Issue Date FY: 2024 ( Subtotal = $413,274 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	8	4/23/2024	NON-COMPETING CONTINUATION	$29,823
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	11/10/2023	NON-COMPETING CONTINUATION	$383,451
														Subtotal = $413,274

Issue Date FY: 2023 ( Subtotal = $483,453 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	7	1/31/2023	NON-COMPETING CONTINUATION	$48,344
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	7	11/21/2022	NON-COMPETING CONTINUATION	$435,109
2023	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	11/15/2022	COMPETING CONTINUATION	$0
														Subtotal = $483,453

Issue Date FY: 2022 ( Subtotal = $483,453 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	12/3/2021	COMPETING CONTINUATION	$483,453
2022	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	6/7/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $483,453

Issue Date FY: 2021 ( Subtotal = $340,990 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	1/11/2021	NON-COMPETING CONTINUATION	$34,099
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	12/2/2020	NON-COMPETING CONTINUATION	$306,891
														Subtotal = $340,990

Issue Date FY: 2020 ( Subtotal = $402,418 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	11/21/2019	NON-COMPETING CONTINUATION	$362,175
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	2/7/2020	NON-COMPETING CONTINUATION	$40,243
														Subtotal = $402,418

Issue Date FY: 2019 ( Subtotal = $444,421 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	11/27/2018	NON-COMPETING CONTINUATION	$444,421
														Subtotal = $444,421

Issue Date FY: 2018 ( Subtotal = $383,049 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	11/22/2017	NON-COMPETING CONTINUATION	$306,891
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	2	9/5/2018	SUPPLEMENT FOR EXPANSION	$42,059
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	5/7/2018	NON-COMPETING CONTINUATION	$34,099
														Subtotal = $383,049

Issue Date FY: 2017 ( Subtotal = $300,040 )
2017	2017	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	11/21/2016	NEW	$300,040
														Subtotal = $300,040

Grand Total All Awards = $4,050,104

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A Functional Taxonomy of Cortical Astrocytes

Award Number: R01NS099254

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/2016

PERIOD OF PERFORMANCE END DATE: 11/30/2026

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