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Interrogating Neuronal Membrane Potential Dynamics with Optical Voltage Sensors

Award Number: R01NS098088
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2017
PERIOD OF PERFORMANCE END DATE: 12/31/2026

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Interrogating Neuronal Membrane Potential Dynamics with Optical Voltage Sensors - 07 Project Summary/Abstract The long-term goal of this project is to interrogate the dynamics of membrane voltage in the context of intact brains with high spatiotemporal resolution. Optical methods to dissect neuronal activity promise to revolutionize our understanding of the brain at the cellular and circuit level; however, our understanding remains incomplete due, in part, to a lack of tools that can report directly on neuronal activity with sufficient speed and sensitivity. We propose to use the power of molecular design and organic chemistry to develop and apply new optical tools for monitoring membrane potential with unprecedented speed and sensitivity in intact brains and without disruptive capacitive load associated with other classes of voltage indicators. We plan to exploit photoinduced electron transfer (PeT) through molecular wires as a versatile platform for optical voltage sensing. We will build a palette of colors for optical voltage sensing that extends into the near infrared regions of the electromagnetic spectrum; we will create new voltage sensors with exceptionally high two-photon absorption cross sections for use in thick tissue and intact brains; and we will explore methods for genetically targeting and localizing ultra- sensitive fluorescent voltage sensors to neurons of interest. Throughout, development of molecular tools will be closely wed to applications in neurons and tissues, and we will apply these tools to understand how membrane potential dynamics change in both healthy and neurological disease states.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $449,080 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	10	1/22/2026	NON-COMPETING CONTINUATION	$449,080
														Subtotal = $449,080

Issue Date FY: 2025 ( Subtotal = $554,522 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	9	9/11/2025	SUPPLEMENT FOR EXPANSION	$55,753
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	1/24/2025	NON-COMPETING CONTINUATION	$498,769
														Subtotal = $554,522

Issue Date FY: 2024 ( Subtotal = $635,708 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	8	7/1/2024	SUPPLEMENT FOR EXPANSION	$24,700
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	8	4/11/2024	NON-COMPETING CONTINUATION	$38,978
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	1/29/2024	NON-COMPETING CONTINUATION	$501,152
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	8	5/20/2024	SUPPLEMENT FOR EXPANSION	$70,878
														Subtotal = $635,708

Issue Date FY: 2023 ( Subtotal = $559,483 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	3/8/2023	NON-COMPETING CONTINUATION	$559,483
														Subtotal = $559,483

Issue Date FY: 2022 ( Subtotal = $562,131 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	6	8/23/2022	COMPETING CONTINUATION	$18
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	12/3/2021	COMPETING CONTINUATION	$562,131
2022	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	8/23/2022	NON-COMPETING CONTINUATION	-$18
														Subtotal = $562,131

Issue Date FY: 2021 ( Subtotal = $324,144 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	12/24/2020	NON-COMPETING CONTINUATION	$291,729
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	1/11/2021	NON-COMPETING CONTINUATION	$32,415
														Subtotal = $324,144

Issue Date FY: 2020 ( Subtotal = $324,707 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	2/7/2020	NON-COMPETING CONTINUATION	$32,471
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	1/10/2020	NON-COMPETING CONTINUATION	$292,236
														Subtotal = $324,707

Issue Date FY: 2019 ( Subtotal = $329,798 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	1/18/2019	NON-COMPETING CONTINUATION	$329,798
														Subtotal = $329,798

Issue Date FY: 2018 ( Subtotal = $291,218 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	4/25/2018	NON-COMPETING CONTINUATION	$29,122
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	12/13/2017	NON-COMPETING CONTINUATION	$262,096
														Subtotal = $291,218

Issue Date FY: 2017 ( Subtotal = $282,498 )
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	12/22/2016	NEW	$282,498
														Subtotal = $282,498

Grand Total All Awards = $4,313,289

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Interrogating Neuronal Membrane Potential Dynamics with Optical Voltage Sensors

Award Number: R01NS098088

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2017

PERIOD OF PERFORMANCE END DATE: 12/31/2026

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