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Mechanism of touch sensitivity in rapidly-adapting mechanosensory corpuscles

Award Number: R01NS097547
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/2016
PERIOD OF PERFORMANCE END DATE: 01/31/2027

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Mechanism of touch sensitivity in rapidly-adapting mechanosensory corpuscles - The ability to sense the world though physical contact is essential for all living organisms. In vertebrates, transient touch and vibration are detected by Pacinian corpuscles, but the mechanism of their function is poorly understood. Pacinian corpuscles are innervated by rapidly-adapting mechanoreceptor afferents, which detect touch due to expression of mechanically activated ion channels. The mechanoreceptor is surrounded by inner core cells, which are thought to provide auxiliary non-sensory support for the mechanoreceptor. Here, we will functionally test the hypothesis that inner core cells of Pacinian corpuscles are active touch sensors. We seek to reveal the molecular mechanism of touch sensitivity and touch-evoked excitability in inner core cells, and determine the effect of inner core cell activation on mechanoreceptor function. To do this, we will use bill skin of tactile specialist ducks, which contains a high density of Pacinian corpuscles accessible for electrophysiological manipulations. Because Pacinian corpuscles are present in the skin or internal organs of most vertebrates, including all mammals, our results will further our understanding of general molecular and cellular mechanisms of touch detection.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $461,897 )
2026	2026	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	10	2/26/2026	NON-COMPETING CONTINUATION	$461,897
														Subtotal = $461,897

Issue Date FY: 2025 ( Subtotal = $461,897 )
2025	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	4/17/2025	NON-COMPETING CONTINUATION	$461,897
														Subtotal = $461,897

Issue Date FY: 2024 ( Subtotal = $448,039 )
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	8	5/1/2024	NON-COMPETING CONTINUATION	$32,331
2024	2024	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	2/1/2024	NON-COMPETING CONTINUATION	$415,708
														Subtotal = $448,039

Issue Date FY: 2023 ( Subtotal = $461,897 )
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	1/28/2023	NON-COMPETING CONTINUATION	$461,897
														Subtotal = $461,897

Issue Date FY: 2022 ( Subtotal = $480,459 )
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	6	6/22/2022	COMPETING CONTINUATION	$636
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	1/27/2022	COMPETING CONTINUATION	$480,459
2022	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	6/22/2022	NON-COMPETING CONTINUATION	-$636
														Subtotal = $480,459

Issue Date FY: 2021 ( Subtotal = $366,406 )
2021	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	3/16/2021	NON-COMPETING CONTINUATION	$366,406
														Subtotal = $366,406

Issue Date FY: 2020 ( Subtotal = $366,406 )
2020	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	2/10/2020	NON-COMPETING CONTINUATION	$36,641
2020	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	11/27/2019	NON-COMPETING CONTINUATION	$329,765
														Subtotal = $366,406

Issue Date FY: 2019 ( Subtotal = $366,406 )
2019	2019	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	11/29/2018	NON-COMPETING CONTINUATION	$366,406
														Subtotal = $366,406

Issue Date FY: 2018 ( Subtotal = $366,406 )
2018	2018	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	4/26/2018	NON-COMPETING CONTINUATION	$36,641
2018	2018	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	11/21/2017	NON-COMPETING CONTINUATION	$329,765
														Subtotal = $366,406

Issue Date FY: 2017 ( Subtotal = $366,406 )
2017	2017	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	11/11/2016	NEW	$366,406
														Subtotal = $366,406

Grand Total All Awards = $4,146,219

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Mechanism of touch sensitivity in rapidly-adapting mechanosensory corpuscles

Award Number: R01NS097547

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/2016

PERIOD OF PERFORMANCE END DATE: 01/31/2027

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