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Electrophysiological Source Imaging of Partial Epilepsy

Award Number: R01NS096761
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2016
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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Electrophysiological Source Imaging of Partial Epilepsy - Project Summary The long-term goal of the research program is to develop and establish a novel electrophysiological source imaging technology to localize and image epileptogenic brain tissues aiding pre-surgical planning in focal (partial) epilepsy. Epilepsy is a common neurological disease impacting more than 3.4 million patients in the US and 70 million globally. The standard clinical routine heavily relies on using intracranial EEG (iEEG) implanted into the brain to determine seizure onset zone, to aid in the localization of epileptogenic zone (EZ), despite the limited coverage of iEEG electrodes and invasive nature of the multiple-day procedure. There is a clinical need to develop a noninvasive neuroimaging approach based on electrophysiological recordings that can reliably image and delineate the EZ from relevant epilepsy biomarkers. In this research project, we propose to establish a novel unsupervised machine learning framework that will be able to process unmarked, continuous, and long-term EEG recordings of focal epilepsy patients to detect high frequency oscillations (HFOs), automatically identify the pathological HFOs (pHFOs, i.e., HFOs riding on spikes), and localize and image epileptogenic brain activity from the identified pHFOs. The proposed techniques will be rigorously validated in over 120 focal epilepsy patients against clinical findings from iEEG recordings and surgical resection outcomes. Our specific aims are: Aim 1. Development and evaluation of a novel unsupervised machine learning technique to identify pathological HFOs from continuous EEG recordings. This aim will establish a novel unsupervised machine learning approach for automatically identifying pHFOs originated from epileptogenic activity, by incorporating data-driven feature learning methods. Aim 2. Development and validation of a novel brain tensor decomposition imaging approach for HFO source imaging. We will develop a novel source imaging framework imaging epileptic sources in temporal, spectral, and spatial domains. This aim will establish a novel data-driven source imaging approach for accurate mapping and localization of EZ from scalp recorded pHFOs. Aim 3: Validation of scalp-detected pHFOs by iEEG-identified pHFOs, with clinical findings of EZ in focal epilepsy patients. We will test the hypothesis that the scalp-EEG identified pHFO events reflect the essential features of iEEG-identified pHFOs, and that both are indicative of the EZ determined from clinical iEEG and confirmed by surgical resection outcome. This aim will establish the relationship between scalp-identified pHFOs with iEEG-identified pHFOs and the underlying epileptogenic networks. The successful completion of the proposed research will establish a novel unsupervised machine learning technology to detect and identify pathological HFOs from continuous and long-term scalp EEG recordings, and localize and image the underlying epileptogenic zone noninvasively and accurately. The establishment of such novel technology promises to significantly improve the clinical management of focal drug- resistant epilepsy, which is currently limited, benefiting numerous patients and the healthcare system.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $468,686 )
2025	2025	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	3/28/2025	NON-COMPETING CONTINUATION	$468,686
														Subtotal = $468,686

Issue Date FY: 2024 ( Subtotal = $512,002 )
2024	2024	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	8	6/27/2024	NON-COMPETING CONTINUATION	$512,002
2024	2022	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	6	10/18/2023	COMPETING CONTINUATION	$16,690
2024	2019	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	10/18/2023	NON-COMPETING CONTINUATION	-$16,690
														Subtotal = $512,002

Issue Date FY: 2023 ( Subtotal = $541,988 )
2023	2023	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	4/5/2023	NON-COMPETING CONTINUATION	$541,988
														Subtotal = $541,988

Issue Date FY: 2022 ( Subtotal = $554,563 )
2022	2022	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	6	3/29/2022	COMPETING CONTINUATION	$554,563
2022	2019	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	3/22/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $554,563

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	5/24/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $357,472 )
2019	2019	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	5/29/2019	NON-COMPETING CONTINUATION	$357,472
														Subtotal = $357,472

Issue Date FY: 2018 ( Subtotal = $360,619 )
2018	2018	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	4	5/9/2018	NON-COMPETING CONTINUATION	$371,997
2018	2017	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	005	3	6/19/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$185,693
2018	2017	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	004	2	6/19/2018	NON-COMPETING CONTINUATION	-$86,715
2018	2017	CARNEGIE MELLON UNIVERSITY	5000 FORBES AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	3/26/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$263,690
2018	2017	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	3/26/2018	NON-COMPETING CONTINUATION	-$275,068
2018	2016	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	1	6/19/2018	NEW	-$98,978
														Subtotal = $360,619

Issue Date FY: 2017 ( Subtotal = $361,783 )
2017	2017	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	5/25/2017	NON-COMPETING CONTINUATION	$36,178
2017	2017	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	4/20/2017	NON-COMPETING CONTINUATION	$325,605
														Subtotal = $361,783

Issue Date FY: 2016 ( Subtotal = $374,783 )
2016	2016	UNIVERSITY OF MINNESOTA, OFFICE OF STUDENT FINANCE AID	106 PLEASANT SE, 210 FRASER HL	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	5/30/2016	NEW	$319,994
2016	2016	UNIVERSITY OF MINNESOTA, OFFICE OF STUDENT FINANCE AID	106 PLEASANT SE, 210 FRASER HL	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	6/8/2016	NEW	$54,789
														Subtotal = $374,783

Grand Total All Awards = $3,531,896

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Electrophysiological Source Imaging of Partial Epilepsy

Award Number: R01NS096761

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2016

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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