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Neurogenetic Approaches to Study Directed Behavior in Drosophilla

Award Number: R01NS086859
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2014
PERIOD OF PERFORMANCE END DATE: 12/15/2024

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Neurogenetic Approaches to Study Directed Behavior in Drosophilla - PROJECT SUMMARY: The long term goal is to provide a framework to understand how a simple, innate behavior emerges from the activity of the nervous system. For this, molecular genetics techniques, electrophysiology and imaging technologies to study the mechanisms underlying temperature processing and preference in Drosophila -a system ideally suited for a comprehensive genetic and molecular dissection of neural circuits and behaviors, are applied. The lab's recent work has demonstrated that a simple sensory map represents temperature stimuli in the fly brain. It has also shown that a coordinated ensemble of second order neurons extracts information about the sign, onset, magnitude and duration of a temperature change from this simple map. The research is now proposing to delve deeper into the cellular and molecular mechanism that make this transformation possible. The expectation is that the results of this work will reveal new mechanisms and principles of somatosensory processing in the nervous system, will complement discoveries on differential feature extraction in other sensory modalities, and will have implications of interest to the broader neuroscience community, informing work on information processing within neural circuits. This work is also expected to contribute to the general understanding of the function of the neural circuits that control somatosensory responses (temperature and pain) in animals, potentially providing insights on genetic and neurological conditions which affect neuronal excitability resulting in devastating medical conditions such as chronic pain.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $510,218 )
2025	2025	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	11	12/13/2024	COMPETING CONTINUATION	$510,218
2025	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	10	5/14/2025	NON-COMPETING CONTINUATION	$0
2025	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	10	12/5/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $510,218

Issue Date FY: 2023 ( Subtotal = $442,864 )
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	10	4/6/2023	NON-COMPETING CONTINUATION	$442,864
														Subtotal = $442,864

Issue Date FY: 2022 ( Subtotal = $443,084 )
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	4/8/2022	NON-COMPETING CONTINUATION	$443,084
														Subtotal = $443,084

Issue Date FY: 2021 ( Subtotal = $524,999 )
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	3/17/2021	NON-COMPETING CONTINUATION	$524,999
														Subtotal = $524,999

Issue Date FY: 2020 ( Subtotal = $442,257 )
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	3/13/2020	NON-COMPETING CONTINUATION	$442,257
														Subtotal = $442,257

Issue Date FY: 2019 ( Subtotal = $460,861 )
2019	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST EVANSTON	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	11/12/2018	COMPETING CONTINUATION	$460,861
2019	2018	NORTHWESTERN UNIVERSITY	633 CLARK	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	9/10/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $460,861

Issue Date FY: 2018 ( Subtotal = $326,853 )
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST EVANSTON	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	5/9/2018	NON-COMPETING CONTINUATION	$32,686
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST EVANSTON	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	3/26/2018	NON-COMPETING CONTINUATION	$294,167
														Subtotal = $326,853

Issue Date FY: 2017 ( Subtotal = $327,383 )
2017	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST EVANSTON	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	4/12/2017	NON-COMPETING CONTINUATION	$294,644
2017	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST EVANSTON	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	6/19/2017	NON-COMPETING CONTINUATION	$32,739
														Subtotal = $327,383

Issue Date FY: 2016 ( Subtotal = $324,527 )
2016	2016	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	3/23/2016	NON-COMPETING CONTINUATION	$324,527
														Subtotal = $324,527

Issue Date FY: 2015 ( Subtotal = $325,167 )
2015	2015	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	4/3/2015	NON-COMPETING CONTINUATION	$325,167
														Subtotal = $325,167

Issue Date FY: 2014 ( Subtotal = $325,776 )
2014	2014	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	2/11/2014	NEW	$325,776
														Subtotal = $325,776

Grand Total All Awards = $4,453,989

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Neurogenetic Approaches to Study Directed Behavior in Drosophilla

Award Number: R01NS086859

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2014

PERIOD OF PERFORMANCE END DATE: 12/15/2024

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