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The Development and Integration of Early Born SST-Expressing Interneurons in the Cortex

Award Number: R01NS081297
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2012
PERIOD OF PERFORMANCE END DATE: 11/30/2028

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The Development and Integration of Early Born SST-Expressing Interneurons in the Cortex - Project Summary In this grant we propose three aims focused on exploring the following: (Aim 1) Determine the efferent target selectivity of granular and infragranular SST cINs and determine the developmental strategy by which this is achieved. (Aim 2) Explore the developmental molecular and cellular basis by which SST cIN diversity is generated. (Aim 3) Identify and validate the SST prototypes during late embryonic and early developmental periods that give rise to the nine SST cIN cell types that populate the mature cortex. A chief goal of my laboratory is to determine cortical interneuron diversity contributes selectively to cortical function and how perturbations in these programs result in brain disease. This grant is an exemplar of the multidisciplinary approaches that has become our hallmark and combines individuals with skills ranging from molecular biology, transcriptomic analysis, genetics and physiology. By combining these with the Fishell laboratory's expertise in development, genetics and circuit formation, we will explore in this proposal how developmental programs in SST cINs shape them selective synaptic connectivity. Together, this grant represents a broad scale effort to both develop and test the proposition that cortical circuits are much more precisely crafted such that the bewildering diversity we have discovered in excitatory and inhibitory neurons reflects a level of circuit organization that we are only beginning to understand. From our preliminary data it is evident that canonical cortical circuits are much more precise and specific to particular subtypes. By defining their relationships, as well as the molecular mechanisms that dictate their synaptic specificity, this work will greatly increase both our understanding of cINs, as well as the microcircuits they contribute to. This in turn will greatly extend our understanding of how discrete cIN and pyramidal neurons interact in the obligate lock and key mechanisms that allow their assembly.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $526,463 )
2025	2025	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	12	11/27/2024	NON-COMPETING CONTINUATION	$526,463
2025	2024	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	11	11/25/2024	COMPETING CONTINUATION	$4,343
2025	2022	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	10	11/25/2024	NON-COMPETING CONTINUATION	-$4,343
														Subtotal = $526,463

Issue Date FY: 2024 ( Subtotal = $531,149 )
2024	2024	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	11	12/26/2023	COMPETING CONTINUATION	$531,149
2024	2022	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	10	11/29/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $531,149

Issue Date FY: 2022 ( Subtotal = $532,008 )
2022	2022	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	10	6/10/2022	NON-COMPETING CONTINUATION	$532,008
														Subtotal = $532,008

Issue Date FY: 2021 ( Subtotal = $535,658 )
2021	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	5/28/2021	NON-COMPETING CONTINUATION	$535,658
														Subtotal = $535,658

Issue Date FY: 2020 ( Subtotal = $539,690 )
2020	2020	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	6/1/2020	NON-COMPETING CONTINUATION	$539,690
														Subtotal = $539,690

Issue Date FY: 2019 ( Subtotal = $543,653 )
2019	2019	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	7	6/7/2019	NON-COMPETING CONTINUATION	$543,653
2019	2018	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	6	3/26/2019	COMPETING CONTINUATION	$3,640
2019	2017	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	3/26/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$3,640
														Subtotal = $543,653

Issue Date FY: 2018 ( Subtotal = $551,480 )
2018	2018	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	004	6	9/22/2018	COMPETING CONTINUATION	$16,219
2018	2018	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	6	6/15/2018	COMPETING CONTINUATION	$551,480
2018	2017	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	12/14/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$2,776
2018	2017	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	5	9/22/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$16,219
2018	2016	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	12/14/2017	EXTENSION WITH OR WITHOUT FUNDS	-$2,776
														Subtotal = $551,480

Issue Date FY: 2017 ( Subtotal = $333,987 )
2017	2017	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	5	8/3/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$334,905
2017	2016	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	11/30/2016	EXTENSION WITH OR WITHOUT FUNDS	$96,564
2017	2015	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	11/30/2016	NON-COMPETING CONTINUATION	-$96,564
2017	2013	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	HHS Programs for Disaster Relief Appropriations Act - Non Construction	002	2	7/6/2017	SUPPLEMENT FOR EXPANSION	-$918
														Subtotal = $333,987

Issue Date FY: 2016 ( Subtotal = $369,688 )
2016	2016	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	5/31/2016	EXTENSION WITH OR WITHOUT FUNDS	$369,688
														Subtotal = $369,688

Issue Date FY: 2015 ( Subtotal = $369,688 )
2015	2015	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	7/16/2015	NON-COMPETING CONTINUATION	$369,688
														Subtotal = $369,688

Issue Date FY: 2013 ( Subtotal = $713,235 )
2013	2013	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	9/11/2013	NON-COMPETING CONTINUATION	$0
2013	2013	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	HHS Programs for Disaster Relief Appropriations Act - Non Construction	002	2	9/11/2013	SUPPLEMENT FOR EXPANSION	$356,486
2013	2013	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	5/29/2013	NON-COMPETING CONTINUATION	$356,749
														Subtotal = $713,235

Issue Date FY: 2012 ( Subtotal = $369,688 )
2012	2012	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	8/24/2012	NEW	$369,688
														Subtotal = $369,688

Grand Total All Awards = $5,916,387

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The Development and Integration of Early Born SST-Expressing Interneurons in the Cortex

Award Number: R01NS081297

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2012

PERIOD OF PERFORMANCE END DATE: 11/30/2028

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