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MAPPING CONNECTIVITY ONTO POSTNATAL-BORN NEURONS

Award Number: R01NS078294
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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MAPPING CONNECTIVITY ONTO POSTNATAL-BORN NEURONS - Continued neurogenesis represents a remarkable means of cellular and structural neural plasticity in adult brain tissue, and elucidating the fundamental mechanisms that support and guide this phenomenon holds promise towards developing future approaches towards repairing damaged or diseased nervous tissue. Data have shown that numerous extrinsic physiological and pathological processes directly influence adult neurogenesis and synaptic integration of newborn neurons. Notably, increased neural activity enhances adult neurogenesis, synaptogenesis, and circuit remodeling, whereas decreased or altered neural activity compromises newborn neuron survival and integration. To date however, the identities of inputs that convey activity-dependent changes to newborn neurons, and the nature of their signaling in response to activity manipulations are only now beginning to be revealed. In the previous granting period of this award, we have identified previously unknown sources of input, and revealed novel neuromodulatory signaling mechanisms that contribute towards the activity- dependent wiring of newborn neurons in the adult brain. Here we will expand upon these findings to better understand the cellular mechanisms that promote the formation and stabilization of new synapses in adult brain tissue, and further assay how manipulating these pathways affects the formation and/or remodeling of new brain circuits.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $350,000 )
2023	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	10	3/1/2023	NON-COMPETING CONTINUATION	$350,000
														Subtotal = $350,000

Issue Date FY: 2022 ( Subtotal = $350,000 )
2022	2022	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	3/1/2022	NON-COMPETING CONTINUATION	$315,000
2022	2022	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	9	3/28/2022	NON-COMPETING CONTINUATION	$35,000
														Subtotal = $350,000

Issue Date FY: 2021 ( Subtotal = $350,000 )
2021	2021	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	2/24/2021	NON-COMPETING CONTINUATION	$350,000
														Subtotal = $350,000

Issue Date FY: 2020 ( Subtotal = $350,000 )
2020	2020	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	2/24/2020	NON-COMPETING CONTINUATION	$350,000
														Subtotal = $350,000

Issue Date FY: 2019 ( Subtotal = $348,906 )
2019	2019	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	6	3/1/2019	COMPETING CONTINUATION	$348,906
2019	2019	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	6	7/11/2019	COMPETING CONTINUATION	$25,033
2019	2016	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	2/27/2019	EXTENSION WITH OR WITHOUT FUNDS	$0
2019	2016	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	5	7/11/2019	EXTENSION WITH OR WITHOUT FUNDS	-$25,033
														Subtotal = $348,906

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2016	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	3/9/2018	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $342,344 )
2016	2016	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	3/28/2016	EXTENSION WITH OR WITHOUT FUNDS	$342,344
														Subtotal = $342,344

Issue Date FY: 2015 ( Subtotal = $309,734 )
2015	2015	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	3/21/2015	NON-COMPETING CONTINUATION	$342,344
2015	2014	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	3/20/2015	NON-COMPETING CONTINUATION	-$32,610
														Subtotal = $309,734

Issue Date FY: 2014 ( Subtotal = $394,813 )
2014	2014	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	3/18/2014	NON-COMPETING CONTINUATION	$394,813
														Subtotal = $394,813

Issue Date FY: 2013 ( Subtotal = $384,843 )
2013	2013	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	3/19/2013	NON-COMPETING CONTINUATION	$358,921
2013	2013	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	5/29/2013	NON-COMPETING CONTINUATION	$25,922
														Subtotal = $384,843

Issue Date FY: 2012 ( Subtotal = $398,801 )
2012	2012	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	7/9/2012	SUPPLEMENT FOR EXPANSION	$56,457
2012	2012	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	3/8/2012	NEW	$342,344
														Subtotal = $398,801

Grand Total All Awards = $3,579,441

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MAPPING CONNECTIVITY ONTO POSTNATAL-BORN NEURONS

Award Number: R01NS078294

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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