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Dissecting the roles of neuromodulation and neural activity in neurovascular coupling during behavior

Award Number: R01NS078168
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract Changes in neural activity drive changes in local blood flow in the brain. These changes in cerebral hemodynamics are important for maintaining normal brain health, and are used for non-invasively inferring neural activity. However, hemodynamic signals can decouple from local neural activity, making the understanding of the mechanism of this decoupling critical for interpreting and decoding hemodynamic signals. We hypothesize that hemodynamic signals in a given brain area are controlled by both vasodilatory signals released by local neurons, and by vasoconstrictory neuromodulation, specifically noradrenaline, both of which will vary with behavioral state, such locomotion. We will mechanistically test this hypothesis using optical imaging (intrinsic optical signal imaging and 2-photon microscopy), local pharmacological infusions, chemogenetics, oxygen polarography, and electrophysiology in awake mice. These experiments will elucidate how noradrenergic modulation, which is involved in alertness and attention, interacts with local neural activity to generate changes in blood flow and oxygenation. The end result of these experiments will be a unified understanding of how neural activity and neuromodulation control hemodynamic signals during behavior. 1


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $347,037 )
2023	2023	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	10	2/8/2023	NON-COMPETING CONTINUATION	$347,037


Issue Date FY: 2022 ( Subtotal = $347,139 )
2022	2022	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	9	4/6/2022	NON-COMPETING CONTINUATION	$34,714
2022	2022	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	2/1/2022	NON-COMPETING CONTINUATION	$312,425


Issue Date FY: 2021 ( Subtotal = $347,237 )
2021	2021	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	5/5/2021	NON-COMPETING CONTINUATION	$347,237


Issue Date FY: 2020 ( Subtotal = $347,331 )
2020	2020	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	3/25/2020	NON-COMPETING CONTINUATION	$347,331


Issue Date FY: 2019 ( Subtotal = $347,422 )
2019	2019	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	12/17/2018	COMPETING CONTINUATION	$347,422
2019	2017	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	6/7/2019	NON-COMPETING CONTINUATION	$0
2019	2017	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	5	8/13/2019	NON-COMPETING CONTINUATION	$0


Issue Date FY: 2017 ( Subtotal = $317,598 )
2017	2017	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	1/30/2017	NON-COMPETING CONTINUATION	$285,838
2017	2017	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	5/26/2017	NON-COMPETING CONTINUATION	$31,760


Issue Date FY: 2016 ( Subtotal = $317,996 )
2016	2016	PENNSYLVANIA STATE UNIVERSITY	110 TECHNOLOGY CENTER BUILDING	UNIVERSITY PARK	PA	16802	CENTRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	1/29/2016	EXTENSION WITH OR WITHOUT FUNDS	$317,996


Issue Date FY: 2015 ( Subtotal = $318,373 )
2015	2015	PENNSYLVANIA STATE UNIVERSITY	110 TECHNOLOGY CENTER BUILDING	UNIVERSITY PARK	PA	16802	CENTRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	1/19/2015	NON-COMPETING CONTINUATION	$318,373


Issue Date FY: 2014 ( Subtotal = $315,547 )
2014	2014	PENNSYLVANIA STATE UNIVERSITY	110 TECHNOLOGY CENTER BUILDING	UNIVERSITY PARK	PA	16802	CENTRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	1/8/2014	NON-COMPETING CONTINUATION	$286,861
2014	2014	PENNSYLVANIA STATE UNIVERSITY	110 TECHNOLOGY CENTER BUILDING	UNIVERSITY PARK	PA	16802	CENTRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	3/10/2014	NON-COMPETING CONTINUATION	$28,686


Issue Date FY: 2013 ( Subtotal = $316,504 )
2013	2013	PENNSYLVANIA STATE UNIVERSITY	110 TECHNOLOGY CENTER BUILDING	UNIVERSITY PARK	PA	16802	CENTRE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	3/1/2013	NEW	$316,504


Grand Total All Awards = $3,322,184

Sum of Action Amount is $3,322,184;

Grand Total = $3,322,184

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Dissecting the roles of neuromodulation and neural activity in neurovascular coupling during behavior

Award Number: R01NS078168

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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