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Mechanisms Underlying Cognitive Dysfuntion

Award Number: R01NS076708
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

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ABSTRACT Down syndrome (DS) is the most common genetic cause of intellectual disability and a huge biomedical problem of increasing concern. Currently, there are no treatments that can prevent, delay, or restore deficits in learning and memory associated with DS. Thus, the identification of novel neuronal targets for the development of pharmacotherapies to treat memory decline associated with DS is an important goal. It has been hypothesized that alterations in protein synthesis (mRNA translation) could contribute to the molecular, synaptic, and behavioral abnormalities of neurodevelopmental disorders, but whether dysfunctional protein synthesis is responsible for the DS pathology remains unknown. The goal of this competing renewal is to identify and correct the aberrant translational control program underlying DS pathophysiology. We focus on protein synthesis controlled by the PKR-eIF2a signaling pathway because a) our preliminary findings indicate that PKR-eIF2a signaling is selectively perturbed in the DS brain, and b) during the previous funding period, we discovered PKR-eIF2a signaling as a central mechanism regulating not only the formation of long-term memory, but also the two major and opposing forms of synaptic plasticity in the brain. We will combine genetics, state-of-the-art intersectional molecular genetic approaches, pharmacology, electrophysiology, cell- type-specific manipulation, genomics, and behavior to define the translational and synaptic plasticity mechanisms underlying cognitive deficits in Down syndrome. We anticipate that the results of these Aims will provide new fundamental insights into the biological basis of intellectual disability and could open avenues for new therapies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $852,716 )
2024	2024	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	13	4/5/2024	NON-COMPETING CONTINUATION	$852,716
2024	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	12	3/22/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $852,716

Issue Date FY: 2023 ( Subtotal = $884,285 )
2023	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	12	5/18/2023	NON-COMPETING CONTINUATION	$0
2023	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	12	4/17/2023	NON-COMPETING CONTINUATION	$884,285
														Subtotal = $884,285

Issue Date FY: 2022 ( Subtotal = $890,226 )
2022	2022	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	11	7/29/2022	NON-COMPETING CONTINUATION	$890,226
2022	2020	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	2/28/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $890,226

Issue Date FY: 2021 ( Subtotal = $911,165 )
2021	2021	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	10	4/15/2021	COMPETING CONTINUATION	$911,165
2021	2020	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	10/21/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $911,165

Issue Date FY: 2020 ( Subtotal = $457,639 )
2020	2020	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	5/27/2020	NON-COMPETING CONTINUATION	$457,639
														Subtotal = $457,639

Issue Date FY: 2019 ( Subtotal = $457,639 )
2019	2019	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	5/24/2019	NON-COMPETING CONTINUATION	$457,639
														Subtotal = $457,639

Issue Date FY: 2018 ( Subtotal = $455,023 )
2018	2018	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	7	4/30/2018	NON-COMPETING CONTINUATION	$455,023
2018	2017	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	6	1/29/2018	COMPETING CONTINUATION	$67,420
2018	2016	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	1/29/2018	EXTENSION WITH OR WITHOUT FUNDS	-$67,420
														Subtotal = $455,023

Issue Date FY: 2017 ( Subtotal = $455,023 )
2017	2017	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	6	6/9/2017	COMPETING CONTINUATION	$455,023
2017	2016	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	6/6/2017	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $455,023

Issue Date FY: 2016 ( Subtotal = $342,344 )
2016	2016	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	3/14/2016	EXTENSION WITH OR WITHOUT FUNDS	$342,344
														Subtotal = $342,344

Issue Date FY: 2015 ( Subtotal = $342,344 )
2015	2015	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	1/26/2015	NON-COMPETING CONTINUATION	$342,344
														Subtotal = $342,344

Issue Date FY: 2014 ( Subtotal = $338,921 )
2014	2014	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	1/24/2014	NON-COMPETING CONTINUATION	$308,109
2014	2014	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	3/10/2014	NON-COMPETING CONTINUATION	$30,812
														Subtotal = $338,921

Issue Date FY: 2013 ( Subtotal = $330,362 )
2013	2013	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	1/31/2013	NON-COMPETING CONTINUATION	$308,109
2013	2013	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	5/23/2013	NON-COMPETING CONTINUATION	$22,253
														Subtotal = $330,362

Issue Date FY: 2012 ( Subtotal = $342,344 )
2012	2012	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	3/12/2012	NEW	$342,344
														Subtotal = $342,344

Grand Total All Awards = $7,060,031

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Mechanisms Underlying Cognitive Dysfuntion

Award Number: R01NS076708

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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