Sunday, May 11, 2025 5/11/2025

The integrated stress response in cognitive disorders

Award Number: R01NS076708
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Description

The integrated stress response in cognitive disorders - ABSTRACT Cognitive disorders pose a major threat to public health, and represent an enormous economic and social burden. Despite the high incidence of these disorders, effective treatments remain severely limited. Thus, the development of novel therapeutic to treat cognitive disorders is an important goal. Here we focus on the integrated stress response (ISR), a conserved signaling network that restores protein homeostasis by regulating protein synthesis, and a main causative pathway underlying the memory deficits associated with a wide range of cognitive disorders. The goal of this competing renewal is to define the precise molecular, cellular, and circuit mechanisms by which activation of the ISR leads to cognitive dysfunction. In Aim 1, we will generate and characterize mice carrying a human mutation in a key component of the ISR, which activates the ISR, and is associated with intellectual disability. In Aim 2, we will generate and use state-of-the-art, novel molecular- genetic approaches to identify the specific cell types in the brain driving the long-term memory deficits upon activation of the ISR. Finally, in Aim 3, we will develop a novel high-throughput screening platform to identify new inhibitors of the ISR. The results of these Aims will provide new fundamental insights into the biological basis of cognitive dysfunction and hold the hope of opening new therapeutic avenues for cognitive disorders resulting from perturbation of protein homeostasis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $844,472 )
2025	2025	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	14	3/21/2025	NON-COMPETING CONTINUATION	$844,472
														Subtotal = $844,472

Issue Date FY: 2024 ( Subtotal = $852,716 )
2024	2024	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	13	4/5/2024	NON-COMPETING CONTINUATION	$852,716
2024	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	12	3/22/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $852,716

Issue Date FY: 2023 ( Subtotal = $884,285 )
2023	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	12	4/17/2023	NON-COMPETING CONTINUATION	$884,285
2023	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	12	5/18/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $884,285

Issue Date FY: 2022 ( Subtotal = $890,226 )
2022	2022	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	11	7/29/2022	NON-COMPETING CONTINUATION	$890,226
2022	2020	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	2/28/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $890,226

Issue Date FY: 2021 ( Subtotal = $911,165 )
2021	2021	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	10	4/15/2021	COMPETING CONTINUATION	$911,165
2021	2020	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	10/21/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $911,165

Issue Date FY: 2020 ( Subtotal = $457,639 )
2020	2020	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	5/27/2020	NON-COMPETING CONTINUATION	$457,639
														Subtotal = $457,639

Issue Date FY: 2019 ( Subtotal = $457,639 )
2019	2019	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	5/24/2019	NON-COMPETING CONTINUATION	$457,639
														Subtotal = $457,639

Issue Date FY: 2018 ( Subtotal = $455,023 )
2018	2018	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	7	4/30/2018	NON-COMPETING CONTINUATION	$455,023
2018	2017	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	6	1/29/2018	COMPETING CONTINUATION	$67,420
2018	2016	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	1/29/2018	EXTENSION WITH OR WITHOUT FUNDS	-$67,420
														Subtotal = $455,023

Issue Date FY: 2017 ( Subtotal = $455,023 )
2017	2017	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	6	6/9/2017	COMPETING CONTINUATION	$455,023
2017	2016	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	6/6/2017	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $455,023

Issue Date FY: 2016 ( Subtotal = $342,344 )
2016	2016	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	3/14/2016	EXTENSION WITH OR WITHOUT FUNDS	$342,344
														Subtotal = $342,344

Issue Date FY: 2015 ( Subtotal = $342,344 )
2015	2015	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	1/26/2015	NON-COMPETING CONTINUATION	$342,344
														Subtotal = $342,344

Issue Date FY: 2014 ( Subtotal = $338,921 )
2014	2014	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	3/10/2014	NON-COMPETING CONTINUATION	$30,812
2014	2014	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	1/24/2014	NON-COMPETING CONTINUATION	$308,109
														Subtotal = $338,921

Issue Date FY: 2013 ( Subtotal = $330,362 )
2013	2013	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	5/23/2013	NON-COMPETING CONTINUATION	$22,253
2013	2013	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	1/31/2013	NON-COMPETING CONTINUATION	$308,109
														Subtotal = $330,362

Issue Date FY: 2012 ( Subtotal = $342,344 )
2012	2012	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	3/12/2012	NEW	$342,344
														Subtotal = $342,344

Grand Total All Awards = $7,904,503

Top

All Categories

About

Search

Reports

Data Submission

Award Information

The integrated stress response in cognitive disorders

Award Number: R01NS076708

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer