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CHADSS: Chagas Disease Scan Study

Award Number: R01NS064905
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2011
PERIOD OF PERFORMANCE END DATE: 08/31/2018

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CHADSS: Chagas Disease Scan Study - DESCRIPTION (provided by applicant): Stroke is an enormous international public health concern, particularly in the developing world where there are limited resources available to provide for an aging population. One of the main contributors to stroke incidence is the highly prevalent Chagas disease, a parasitic infection affecting an estimated 18 million individuals and a major cause of heart failure in Latin America. Chagas disease conveys stroke risk through two established mechanisms: structural cardiac disease and chronic inflammation. Although inflammation is associated with an increased risk of ischemic stroke and poorer outcome, its role has been largely linked to atherogenesis. Chronic inflammation can result in endothelial dysfunction and stimulate the hemostatic system, increasing systemic fibrin production and platelet activation. Brain atrophy has also been associated with chronic inflammation. Adults, young and old, who develop a secondary cardiomyopathy from Chagas are therefore at higher risk of cardioembolism and neurodegeneration. Stroke patients usually survive, but can be left with significant disability affecting their health status, productivity, and quality of life. These factors impact caregivers as well. Thus, the social and economic consequences of stroke are vast. During our R21 planning grant period, we were able to establish a collaborative infrastructure between the research groups in Brazil and the United States and collect preliminary data. We found an association between Chagas disease and stroke that was independent of cardiomyopathy. Cognitive impairment and brain atrophy were also associated with Chagas disease independently of cardiomyopathy. Biomarkers orosomucoid, neprilysin, interleukin-6 (IL-6) and matrix metalloproteinase-9 (MMP-9) were identified as diagnostic and therapeutic targets in Chagas disease. As part of this phase, we will address three specific aims: (1) to establish brain magnetic resonance imaging markers of stroke risk in patients with Chagasic congestive heart failure (CM); (2) to determine whether biomarkers can predict stroke risk in patients with Chagasic CM; and (3) to evaluate the efficacy of antiplatelet treatment in decreasing microembolization rate in patients with Chagasic CM. The long-term goal of this project is to establish non-invasive methods of stroke risk stratification and prediction of stroke outcome in patients with Chagas disease. This work will also facilitate the development of novel anti-trypanosomal, anti- inflammatory, and antithrombotic strategies for stroke prevention and management in Brazil.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = -$46,013 )
2021	2015	FUNDACAO DE APOIO A PESQUISA E A EXTENSAO FAPEX	AV. MANOEL DIAS DA SILVA 1.784 ED. COM. PITUBA TRADE	SALVADOR	BA			BRA	Extramural Research Programs in the Neurosciences and Neurological Disorders	005	5	10/3/2020	NON-COMPETING CONTINUATION	$4,391
2021	2015	FUNDACAO DE APOIO A PESQUISA E A EXTENSAO FAPEX	AV. MANOEL DIAS DA SILVA 1.784 ED. COM. PITUBA TRADE	SALVADOR	BA			BRA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	5	10/3/2020	NON-COMPETING CONTINUATION	-$4,391
2021	2015	FUNDACAO DE APOIO A PESQUISA E A EXTENSAO FAPEX	AV. MANOEL DIAS DA SILVA 1.784 ED. COM. PITUBA TRADE	SALVADOR	BA			BRA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	10/1/2020	NON-COMPETING CONTINUATION	-$4,391
2021	2015	FUNDACAO DE APOIO A PESQUISA E A EXTENSAO FAPEX	AV. MANOEL DIAS DA SILVA 1.784 ED. COM. PITUBA TRADE	SALVADOR	BA			BRA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	10/1/2020	NON-COMPETING CONTINUATION	-$42,231
2021	2015	FUNDACAO DE APOIO A PESQUISA E A EXTENSAO FAPEX	AV. MANOEL DIAS DA SILVA 1.784 ED. COM. PITUBA TRADE	SALVADOR	BA			BRA	Extramural Research Programs in the Neurosciences and Neurological Disorders	004	5	10/3/2020	NON-COMPETING CONTINUATION	-$41,622
2021	2015	FUNDACAO DE APOIO A PESQUISA E A EXTENSAO FAPEX	AV. MANOEL DIAS DA SILVA 1.784 ED. COM. PITUBA TRADE	SALVADOR	BA			BRA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	5	10/3/2020	NON-COMPETING CONTINUATION	$42,231
														Subtotal = -$46,013

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2015	FUNDACAO DE APOIO A PESQUISA E A EXTENSAO - FAPEX.	RUA CAETANO MOURA 140	SALVADOR	BA	40210-340		BRA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	1/7/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = -$133,504 )
2018	2015	FUNDACAO DE APOIO A PESQUISA E A EXTENSAO - FAPEX.	RUA CAETANO MOURA 140	SALVADOR	BA	40210-340		BRA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	12/6/2017	NON-COMPETING CONTINUATION	$0
2018	2013	FUNDACAO DE APOIO A PESQUISA E A EXTENSAO - FAPEX.	RUA CAETANO MOURA 140	SALVADOR	BA	40210-340		BRA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	3	9/11/2018	EXTENSION WITH OR WITHOUT FUNDS	-$2,065
2018	2013	FUNDACAO DE APOIO A PESQUISA E A EXTENSAO - FAPEX.	RUA CAETANO MOURA 140	SALVADOR	BA	40210-340		BRA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	9/11/2018	EXTENSION WITH OR WITHOUT FUNDS	-$131,439
														Subtotal = -$133,504

Issue Date FY: 2016 ( Subtotal = $0 )
2016	2015	FUNDACAO DE APOIO A PESQUIS E A EXTENSAO DBA FAPEX	RUA CAETANO MOURA 140	SALVADOR				BRA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	5	11/13/2015	NON-COMPETING CONTINUATION	$53,083
2016	2015	FUNDACAO DE APOIO A PESQUIS E A EXTENSAO DBA FAPEX	RUA CAETANO MOURA 140	SALVADOR				BRA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	11/12/2015	NON-COMPETING CONTINUATION	-$53,083
2016	2014	FUNDACAO DE APOIO A PESQUIS E A EXTENSAO DBA FAPEX	RUA CAETANO MOURA 140	SALVADOR				BRA	Extramural Research Programs in the Neurosciences and Neurological Disorders	004	4	11/13/2015	NON-COMPETING CONTINUATION	$322,098
2016	2014	FUNDACAO DE APOIO A PESQUIS E A EXTENSAO DBA FAPEX	RUA CAETANO MOURA 140	SALVADOR				BRA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	4	11/12/2015	NON-COMPETING CONTINUATION	-$322,098
2016	2013	FUNDACAO DE APOIO A PESQUIS E A EXTENSAO DBA FAPEX	RUA CAETANO MOURA 140	SALVADOR				BRA	Extramural Research Programs in the Neurosciences and Neurological Disorders	005	3	11/13/2015	EXTENSION WITH OR WITHOUT FUNDS	$311,909
2016	2013	FUNDACAO DE APOIO A PESQUIS E A EXTENSAO DBA FAPEX	RUA CAETANO MOURA 140	SALVADOR				BRA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	11/12/2015	EXTENSION WITH OR WITHOUT FUNDS	-$311,909
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $53,083 )
2015	2015	FEDERAL UNIVERSITY OF BAHIA	RUA JOAO DAS BOTAS	BAHIA				BRA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	9/18/2015	NON-COMPETING CONTINUATION	$53,083
														Subtotal = $53,083

Issue Date FY: 2014 ( Subtotal = $322,098 )
2014	2014	FEDERAL UNIVERSITY OF BAHIA	RUA JOAO DAS BOTAS	BAHIA				BRA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	9/18/2014	NON-COMPETING CONTINUATION	$322,098
														Subtotal = $322,098

Issue Date FY: 2013 ( Subtotal = $311,909 )
2013	2013	FEDERAL UNIVERSITY OF BAHIA	HUPES-SERVICO DE IMUNOLOGIA RUA JOA	SALVADOR				BRA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	9/24/2013	EXTENSION WITH OR WITHOUT FUNDS	$311,909
														Subtotal = $311,909

Issue Date FY: 2012 ( Subtotal = $328,494 )
2012	2012	FEDERAL UNIVERSITY OF BAHIA	HUPES-SERVICO DE IMUNOLOGIA RUA JOA	SALVADOR				BRA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	8/25/2012	NON-COMPETING CONTINUATION	$328,494
														Subtotal = $328,494

Issue Date FY: 2011 ( Subtotal = $329,041 )
2011	2011	FEDERAL UNIVERSITY OF BAHIA	HUPES-SERVICO DE IMUNOLOGIA RUA JOA	SALVADOR				BRA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/23/2011	NEW	$329,041
														Subtotal = $329,041

Grand Total All Awards = $1,165,108

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CHADSS: Chagas Disease Scan Study

Award Number: R01NS064905

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2011

PERIOD OF PERFORMANCE END DATE: 08/31/2018

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