Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

MEDIAL TEMPORAL LOBE ROLE IN HUMAN LOCOMOTOR NAVIGATION

Award Number: R01NS052137
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/15/2005
PERIOD OF PERFORMANCE END DATE: 01/31/2009

Group Awards By:

View Award Description

MEDIAL TEMPORAL LOBE ROLE IN HUMAN LOCOMOTOR NAVIGATION - DESCRIPTION (provided by applicant): This project investigates a key issue in human navigation. How does the medial temporal lobe (MTL) process information about space, time, and self-motion to keep us oriented while walking about? Extensive experimentation in rodents indicates that brain structures in the MTL play an important role in navigation, but currently there is a pressing need to validate the relevance of animal studies for understanding human navigation. In addition, there is very little data concerning the effects of brain injury on navigation ability, particularly within the nearby environment. The work in this project will bridge this gap by testing the navigational abilities of patients who have had part of the MTL removed as therapy for severe epilepsy. The project will answer the following questions: (1) Are deficits in navigation after MTL surgery due specifically to removal of MTL tissue, or instead to other factors related to the disease necessitating the surgery? (2) What specifically are the consequences of MTL injury for navigation? (3) How specialized are MTL structures for navigation? (Are only some types of navigation impaired but not others?) (4) Does the right hemisphere MTL play a more dominant role than the left for human navigation? The proposed experiments will provide a firm empirical foundation for understanding the effect of brain injuries and psychiatric disorders that impact the MTL. The work focuses specifically on navigation ability and will be particularly relevant for evaluating the homology of brain structures that subserve navigation in animals and humans. The studies are unique in that they will test a rare population of neurosurgical patients, using methods that focus on the perception of self-motion at an unprecedented level of detail. Furthermore, the methodology will allow an assessment of the possible non-specific effects on navigation of epilepsy and epilepsy medication. This basic data will be highly valuable for interpreting future research involving similar patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2008 ( Subtotal = $196,682 )
2008	2008	GEORGE WASHINGTON UNIVERSITY	2100 M STREET, NW, SUITE 310	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	2/4/2008	NON-COMPETING CONTINUATION	$196,682
														Subtotal = $196,682

Issue Date FY: 2007 ( Subtotal = $163,903 )
2007	2007	GEORGE WASHINGTON UNIVERSITY	2100 M STREET, NW, SUITE 310	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	2/9/2007	NON-COMPETING CONTINUATION	$163,903
														Subtotal = $163,903

Issue Date FY: 2006 ( Subtotal = $168,797 )
2006	2006	GEORGE WASHINGTON UNIVERSITY	2100 M STREET, NW, SUITE 310	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	2/2/2006	NON-COMPETING CONTINUATION	$168,797
														Subtotal = $168,797

Issue Date FY: 2005 ( Subtotal = $172,859 )
2005	2005	GEORGE WASHINGTON UNIVERSITY	2100 M STREET, NW, SUITE 310	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	2/14/2005	NEW	$172,859
														Subtotal = $172,859

Grand Total All Awards = $702,241

Top

All Categories

About

Search

Reports

Data Submission

Award Information

MEDIAL TEMPORAL LOBE ROLE IN HUMAN LOCOMOTOR NAVIGATION

Award Number: R01NS052137

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/15/2005

PERIOD OF PERFORMANCE END DATE: 01/31/2009

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer