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ENDOCRINE BASIS OF NEUROMUSCULAR ATROPHY

Award Number: R01NS051257
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/20/2005
PERIOD OF PERFORMANCE END DATE: 03/31/2009

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ENDOCRINE BASIS OF NEUROMUSCULAR ATROPHY - DESCRIPTION (provided by applicant): The proposed research seeks to understand the contribution of androgen receptor function in skeletal muscle fibers to neuromuscular development and function. Current opinion holds that androgen receptor exerts an anabolic effect on muscle fibers. Contrary to this view, the PI has recently discovered that mice that over-express androgen receptor in muscle fibers develop androgen-dependent muscle wasting (muscular atrophy) and locomotor deficits. The proposed research is a characterization of this muscular atrophy as well as an investigation of its endocrine and molecular basis. The first specific aim examines whether the observed muscular atrophy results in degeneration or death of the motoneurons that innervate these muscles. The subsequent specific aims investigate the contribution of androgenic signaling to the muscular atrophy using endocrine, pharmacological and genetic manipulations of androgen metabolism and androgen receptor function. The proposed research is expected to be beneficial because muscular atrophy is a debilitating aspect of diverse clinical disorders, including spinal and bulbar muscular atrophy (SBMA, also known as Kennedy's disease), a disorder caused by mutant androgen receptors. Because there is currently no effective therapeutic strategy for managing SBMA, investigating the roles of androgen receptor in muscular atrophy may yield valuable insights into potential interventions for this disorder. Furthermore, these studies are expected to increase our understanding of how androgens influence the size and strength of skeletal muscles.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2007 ( Subtotal = $213,127 )
2007	2007	UNIVERSITY OF TORONTO	**	TORONTO, ONTARIO		00000		CAN	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	3/6/2007	NON-COMPETING CONTINUATION	$213,127
														Subtotal = $213,127

Issue Date FY: 2006 ( Subtotal = $219,493 )
2006	2006	UNIVERSITY OF TORONTO	**	TORONTO, ONTARIO		00000		CAN	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	2/16/2006	NON-COMPETING CONTINUATION	$219,493
														Subtotal = $219,493

Issue Date FY: 2005 ( Subtotal = $224,775 )
2005	2005	UNIVERSITY OF TORONTO	**	TORONTO, ONTARIO		00000		CAN	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	5/20/2005	NEW	$224,775
														Subtotal = $224,775

Grand Total All Awards = $657,395

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ENDOCRINE BASIS OF NEUROMUSCULAR ATROPHY

Award Number: R01NS051257

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/20/2005

PERIOD OF PERFORMANCE END DATE: 03/31/2009

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