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ISCHEMIC INJURY OF CNS WHITE MATTER GLIA

Award Number: R01NS044875
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: HEALTH SERVICES
PERIOD OF PERFORMANCE START DATE: 05/01/2002
PERIOD OF PERFORMANCE END DATE: 04/30/2007

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ISCHEMIC INJURY OF CNS WHITE MATTER GLIA - DESCRIPTION (Adapted from applicant's abstract): Immature white matter is subject to ischemic injury during the development of the lesion called periventricular leukomalacia, which is the major pathology, associated with cerebral palsy. The goal of this research is to understand the mechanisms that underlie acute ischemic cell death in immature white matter glial cells. Fluorescent ion-sensitive dyes will be loaded into glial cells in the neonatal rat optic nerve and used to measure changes in intracellular [Ca2+], [Na+] and pH during ischemia in situ. These ionic changes will be correlated to the occurrence of cell death and any casual relationships will be determined. Ionic substitution and drug application will be used to probe mechanisms that underlie ionic derangements that occur in neonatal white matter glia during ischemia. Glial cell types within neonatal white matter are likely to show acute changes in intracellular ions during ischemia due to quite different mechanisms. Live staining of glia in situ will be applied to distinguish astrocytes from oligodendrocytes, allowing both the characteristics of cell death and ionic distribution during ischemia to be analyzed in the two major types of marcoglia present in the CNS. Experiments will test three hypotheses: 1) Acute ischemic astrocyte death at the point in development most at risk (P10nRON), results from Na+ -influx and cell swelling. 2) Na+ -influx/cell swelling also accounts for a significant proportion of acute death of oligodendrocytes and of less mature astrocytes. 3) Non-NMDA glutamate receptors mediate only a proportion of toxic Ca2+ -influx into oligodendroglial during ischemia.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2006 ( Subtotal = $225,425 )
2006	2006	UNIVERSITY OF LEICESTER	UNIVERSITY ROAD	LEICESTER		00000		GBR	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	4/14/2006	NON-COMPETING CONTINUATION	$225,425
														Subtotal = $225,425

Issue Date FY: 2005 ( Subtotal = $230,770 )
2005	2005	UNIVERSITY OF LEICESTER	UNIVERSITY ROAD	LEICESTER		00000		GBR	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	6/2/2005	NON-COMPETING CONTINUATION	$230,770
														Subtotal = $230,770

Issue Date FY: 2004 ( Subtotal = $230,850 )
2004	2004	UNIVERSITY OF LEICESTER	UNIVERSITY ROAD	LEICESTER		00000		GBR	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	4/5/2004	NON-COMPETING CONTINUATION	$230,850
														Subtotal = $230,850

Issue Date FY: 2003 ( Subtotal = $230,850 )
2003	2003	UNIVERSITY OF LEICESTER	UNIVERSITY ROAD	LEICESTER		00000		GBR	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2		NON-COMPETING CONTINUATION	$230,850
														Subtotal = $230,850

Issue Date FY: 2002 ( Subtotal = $222,850 )
2002	2002	UNIVERSITY OF LEICESTER	UNIVERSITY ROAD	LEICESTER		00000		GBR	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	4/17/2002	NEW	$222,850
														Subtotal = $222,850

Grand Total All Awards = $1,140,745

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ISCHEMIC INJURY OF CNS WHITE MATTER GLIA

Award Number: R01NS044875

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: HEALTH SERVICES

PERIOD OF PERFORMANCE START DATE: 05/01/2002

PERIOD OF PERFORMANCE END DATE: 04/30/2007

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