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Dynamic Functional Image-based Deep Learning for Therapy Assessment in Autism

Award Number: R01NS035193
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Dynamic Functional Image-based Deep Learning for Therapy Assessment in Autism - Project Summary Autism spectrum disorder (ASD) is a developmental disorder characterized by impairment of social interaction and communication, as well as repetitive behaviors, with severity ranging from mild to signiﬁcantly disabling. The prevalence in the United States is rising (currently about 1 in 54 children) and the associated costs are enormous. In our most recent previous efforts on this project, we have advanced methods for the analysis of functional magnetic resonance imaging (fMRI), using both task-based and resting-state data, for classiﬁcation, facilitating identiﬁcation of ASD biomarkers, and using these biomarkers for personalized outcome prediction for Pivotal Response Treatment (PRT), an evidence-based form of behavioral therapy for ASD. We have made great strides with our most recent work focusing on deep learning techniques for extracting biomarkers and predicting outcome using novel strategies focusing on temporal characteristics with Long Short Term Memory (LSTM) networks as well as spatial characteristics using Graph Neural Networks (GNNs). Improved use and characterization of the dynamic changes in connectivity appear crucial for advancing performance based both on our work and the literature. Thus, in our proposed work, we intend to develop a richer, integrated model that can more fully exploit the complete spatiotemporal characteristics of the data and its inherent dynamics. In addition, a key issue in deep learning strategies is access to large datasets which remains a challenge, especially given that ASD is a spectrum with a range of characteristics, severity and comorbidities and that fMRI is a powerful tool that encompasses many task-based and resting state acquisition paradigms. Comorbidities are a particular challenge and opportunity in that they have the potential to increase our understanding of the heterogeneous manifestations of ASD. We propose to further develop and expand the power and impact of our methodology by broadening our subject base to include ASD comorbidities (e.g. anxiety, ADHD, depression) and multiple treatment strategies. We will advance our technology by creating a more integrated spatiotemporal analysis combining our LSTM and GNN approaches. We will use domain adaptation methods to properly exploit multiple fMRI paradigms in conjunction with secure federated learning strategies to facilitate multi-institutional data usage with privacy. These innovative approaches will allow us to improve the practicability of predicting quantitative treatment outcomes in ASD and measuring associated neuroimaging biomarkers.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $551,249 )
2025	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	26	3/26/2025	NON-COMPETING CONTINUATION	$551,249
														Subtotal = $551,249

Issue Date FY: 2024 ( Subtotal = $594,123 )
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	25	5/1/2024	NON-COMPETING CONTINUATION	$42,874
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	25	3/21/2024	NON-COMPETING CONTINUATION	$551,249
														Subtotal = $594,123

Issue Date FY: 2023 ( Subtotal = $612,498 )
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	24	3/6/2023	NON-COMPETING CONTINUATION	$612,498
2023	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	23	11/28/2022	COMPETING CONTINUATION	$59,487
2023	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	22	11/28/2022	NON-COMPETING CONTINUATION	-$59,487
														Subtotal = $612,498

Issue Date FY: 2022 ( Subtotal = $637,183 )
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	23	2/24/2022	COMPETING CONTINUATION	$637,183
2022	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	22	2/18/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $637,183

Issue Date FY: 2020 ( Subtotal = $371,982 )
2020	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	22	3/27/2020	NON-COMPETING CONTINUATION	$371,982
														Subtotal = $371,982

Issue Date FY: 2019 ( Subtotal = $371,982 )
2019	2019	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	21	4/10/2019	NON-COMPETING CONTINUATION	$371,982
														Subtotal = $371,982

Issue Date FY: 2018 ( Subtotal = $371,982 )
2018	2018	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	20	5/24/2018	NON-COMPETING CONTINUATION	$371,982
														Subtotal = $371,982

Issue Date FY: 2017 ( Subtotal = $371,982 )
2017	2017	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	19	6/12/2017	NON-COMPETING CONTINUATION	$371,982
2017	2016	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	18	2/1/2017	COMPETING CONTINUATION	$74,862
2017	2015	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	17	2/1/2017	NON-COMPETING CONTINUATION	-$74,862
														Subtotal = $371,982

Issue Date FY: 2016 ( Subtotal = $388,857 )
2016	2016	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	18	8/9/2016	COMPETING CONTINUATION	$388,857
2016	2015	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	065208047	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	17	8/10/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $388,857

Issue Date FY: 2015 ( Subtotal = $359,174 )
2015	2015	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	17	4/23/2015	NON-COMPETING CONTINUATION	$359,174
														Subtotal = $359,174

Issue Date FY: 2014 ( Subtotal = $356,327 )
2014	2014	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	16	4/16/2014	NON-COMPETING CONTINUATION	$356,327
														Subtotal = $356,327

Issue Date FY: 2013 ( Subtotal = $348,034 )
2013	2013	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	15	5/23/2013	NON-COMPETING CONTINUATION	$23,442
2013	2013	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	15	4/19/2013	NON-COMPETING CONTINUATION	$324,592
														Subtotal = $348,034

Issue Date FY: 2012 ( Subtotal = $360,294 )
2012	2012	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	14	4/5/2012	NON-COMPETING CONTINUATION	$360,294
														Subtotal = $360,294

Issue Date FY: 2011 ( Subtotal = $353,349 )
2011	2011	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	13	7/15/2011	COMPETING CONTINUATION	$353,349
														Subtotal = $353,349

Issue Date FY: 2010 ( Subtotal = $0 )
2010	2009	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	12	9/9/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2009 ( Subtotal = $339,441 )
2009	2009	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	12	11/24/2008	NON-COMPETING CONTINUATION	$305,496
2009	2009	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	12	4/6/2009	NON-COMPETING CONTINUATION	$33,945
														Subtotal = $339,441

Issue Date FY: 2008 ( Subtotal = $339,800 )
2008	2008	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	11	1/29/2008	NON-COMPETING CONTINUATION	$339,800
														Subtotal = $339,800

Issue Date FY: 2007 ( Subtotal = $350,363 )
2007	2007	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	10	1/22/2007	NON-COMPETING CONTINUATION	$350,363
														Subtotal = $350,363

Issue Date FY: 2006 ( Subtotal = $361,189 )
2006	2006	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	1/27/2006	NON-COMPETING CONTINUATION	$361,189
														Subtotal = $361,189

Issue Date FY: 2005 ( Subtotal = $358,487 )
2005	2005	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	11/26/2004	COMPETING CONTINUATION	$358,487
														Subtotal = $358,487

Issue Date FY: 2002 ( Subtotal = $268,506 ) (Continued on the next page)
Grand Total All Awards = $9,044,058

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Dynamic Functional Image-based Deep Learning for Therapy Assessment in Autism

Award Number: R01NS035193

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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