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ST3P: A lifestyle walking intervention to improve blood pressure and vascular health in rural cancer survivors

Award Number: R01NR022294
ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/20/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2031

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ST3P: A lifestyle walking intervention to improve blood pressure and vascular health in rural cancer survivors - Cardiovascular disease is a leading cause of death in cancer survivors and disproportionately affects rural communities. The greater cardiovascular risk for rural cancer survivors is due to the negative lasting effects of cancer treatments, like chemotherapy, on the vasculature, and the often-limited access to healthcare facilities and places for traditional cardiovascular disease prevention. Lifestyle physical activity interventions are ideal for rural cancer survivor populations, however we have yet to determine if they are effective for improving objective measures of cardiovascular health. We have assembled a transdisciplinary research team to identify whether a lifestyle walking and habit-formation intervention is effective for improving cardiovascular health and maintaining walking in the long-term. The specific aims of this study are to identify whether a 6-month lifestyle walking and habit-formation intervention 1) lowers blood pressure, 2) improves AI-vascular age, an innovative, point-of-care measure of vascular health, and 3) leads to walking maintenance following the intervention (12-month follow-up) in rural cancer survivors with a history of chemotherapy and elevated blood pressure or Stage 1 hypertension. Participants (n=200) aged 45-79 years will be randomized to either 1) a 6-month lifestyle-walking intervention (+3000 steps/day, 5 days/week) and behavior change counseling or 2) a standard of care control group who receives education information on healthy behaviors. Blood pressure, AI-vascular age, and habit strength and exercise identity will be assessed remotely at baseline, 3-, 6- , and 12-months, in addition to other cardiovascular disease risk factors. This remote clinical trial has potential for immense societal impact via (i) identifying a simple but effective way to improve blood pressure and vascular age with a scalable, decentralized walking intervention primed for broad dissemination that overcomes previous barriers to physical activity, (ii) improving health outcomes by lowering cardiovascular disease burden in high-risk rural cancer survivors, (iii) providing critical information on objective assessments of cardiovascular health that are missing from prior lifestyle physical activity interventions in cancer survivors; and (iv) focusing on habit formation to maintain lifestyle walking past the intervention period for long-term cardiovascular disease risk attenuation. This study will serve as a first step in the long-term goal of optimizing lifestyle physical activity interventions for cardiovascular health and behavior maintenance in rural cancer survivors, a critical population to target to lower cardiovascular disease burden and improve health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $625,339 )
2026	2026	IOWA STATE UNIVERSITY OF SCIENCE AND TECHNOLOGY	1350 BEARDSHEAR HALL	AMES	IA	50011	STORY	USA	Nursing Research	000	1	7/22/2026	NEW	$625,339
														Subtotal = $625,339

Grand Total All Awards = $625,339

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ST3P: A lifestyle walking intervention to improve blood pressure and vascular health in rural cancer survivors

Award Number: R01NR022294

ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/20/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2031

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