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Implementation of an HIV Status-Neutral Nurse-Led Intervention to Improve Clinical Outcomes for Male HIV Self-Testers in Tanzania

Award Number: R01NR021169
ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/25/2024
PERIOD OF PERFORMANCE END DATE: 04/30/2029

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Implementation of an HIV Status-Neutral Nurse-Led Intervention to Improve Clinical Outcomes for Male HIV Self-Testers in Tanzania - There is a need for self-testers in Sub-Saharan Africa (SSA) for follow-up HIV care initiation, including antiretroviral therapy (ART) and pre-exposure prophylaxis (PrEP), following HIV self-testing (HIVST). We piloted the Self-Testing Education and Promotion (STEP) intervention, which included peer education and demand creation for HIVST combined with nurse-led distribution of HIVST kits in a community setting, and found low linkage to facility-up services following HIVST. Based on these findings, we have added the community-based Nurse-Initiated Management of ART (cbNIMART) component to include ART or PrEP initiation following HIVST. There are three aims to this study. Aim 1.) Tailor the STEP+cbNIMART intervention using the ADAPT-ITT model. In Aim 1, the intervention will be further tailored through a “theater test” and feedback from key stakeholders and topical experts, and later utilized for training peer educators and nurses who will help deliver the intervention. Aim 2.) Test the effectiveness of the STEP+cbNIMART intervention on ART or PrEP initiation and retention for self-testers. We will conduct a cluster randomized controlled trial using a hybrid type I implementation-effectiveness study design to assess the effectiveness of the intervention. The trial will include an intervention and control arm, with intervention participants receiving nurse-led community-based ART and PrEP initiation, and control arm participants receiving the standard of care. ART and PrEP adherence will be measured through a baseline survey and subsequent follow-ups of participants in both arms. Aim 3.) Evaluate the facilitators and barriers of implementing the STEP+cbNIMART intervention to refine the intervention for adoption in other settings.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $727,423 )
2025	2025	GEORGE WASHINGTON UNIVERSITY (THE)	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Nursing Research	001	2	8/28/2025	SUPPLEMENT FOR EXPANSION	$51,142
2025	2025	GEORGE WASHINGTON UNIVERSITY (THE)	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Nursing Research	000	2	8/27/2025	NON-COMPETING CONTINUATION	$676,281
														Subtotal = $727,423

Issue Date FY: 2024 ( Subtotal = $783,348 )
2024	2024	GEORGE WASHINGTON UNIVERSITY (THE)	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Nursing Research	000	1	6/25/2024	NEW	$783,348
														Subtotal = $783,348

Grand Total All Awards = $1,510,771

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Implementation of an HIV Status-Neutral Nurse-Led Intervention to Improve Clinical Outcomes for Male HIV Self-Testers in Tanzania

Award Number: R01NR021169

ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/25/2024

PERIOD OF PERFORMANCE END DATE: 04/30/2029

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