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State of Hormones Impact Nociceptive Expression (SHINE)

Award Number: R01NR019417
ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/22/2022
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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State of Hormones Impact Nociceptive Expression (SHINE) - Group differences have been seen in experimental pain tests and hormone levels are often estimated based on biological factors, such as age. To date, it is unknown how circulating hormone levels affect acute pain sensitivity and, given the rise in hormonal supplement usage (i.e., for low testosterone or menopause) and errors in age-based estimations, these data may be critical to assessing potential risk for chronic pain. Further, while we have shown that immune cells are critical to the persistence of chronic pain in animals, it is unclear how circulating hormone levels affect (a) these cell populations in healthy adults, (b) acute pain sensitivity in humans and (c) other psychological factors that may contribute to pain sensitivity. The current project is focused on examining the role that circulating hormones may play in various aspects that contribute to the susceptibility to chronic pain. Specific aims of the study include: 1. To determine the impact of circulating hormone level on pain sensitivity. 2. To quantify differences in immune cell populations and activity. 3. To examine social and psychological factors that contribute to pain sensitivity and the impact of hormones. We will recruit healthy individuals between the ages of 18 and 65 years of age. We will use quantitative sensory testing to assess sensitivity to cold, pressure, and heat via standardized protocols. Blood samples will be taken for assessment of circulating hormone levels (testosterone, estradiol, cortisol), immune cell populations and stimulated cytokine release, as well as salivary samples to measure stress reactivity. Questionnaires will measure pain state, quality of life, self-reported health, sleep, depression, and social support and activity/sleep monitors will provide objective measures of sleep. Together, this will be the first exploration of the impact of circulating hormones on factors that may predispose individuals to chronic pain, carried out in a broad population of healthy adults.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $17,988 )
2025	2025	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Nursing Research	004	4	9/8/2025	NON-COMPETING CONTINUATION	$453,454
2025	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Nursing Research	003	3	8/28/2025	OTHER REVISION	$0
2025	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Nursing Research	000	3	3/14/2025	TERMINATION	$0
2025	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Nursing Research	002	3	6/26/2025	TERMINATION	-$435,466
2025	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Nursing Research	001	3	3/14/2025	TERMINATION	$0
														Subtotal = $17,988

Issue Date FY: 2024 ( Subtotal = $573,819 )
2024	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Nursing Research	000	3	7/16/2024	NON-COMPETING CONTINUATION	$473,872
2024	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Nursing Research	001	3	8/23/2024	SUPPLEMENT FOR EXPANSION	$99,947
														Subtotal = $573,819

Issue Date FY: 2023 ( Subtotal = $482,566 )
2023	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Nursing Research	002	2	7/14/2023	NON-COMPETING CONTINUATION	$482,566
2023	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Nursing Research	000	1	10/12/2022	NEW	$0
2023	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Nursing Research	001	1	11/4/2022	NEW	$0
														Subtotal = $482,566

Issue Date FY: 2022 ( Subtotal = $472,384 )
2022	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Nursing Research	000	1	9/22/2022	NEW	$472,384
														Subtotal = $472,384

Grand Total All Awards = $1,546,757

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State of Hormones Impact Nociceptive Expression (SHINE)

Award Number: R01NR019417

ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/22/2022

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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