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Targeting Autonomic Flexibility to Enhance Cognitive Training Outcomes in Older Adults with Mild Cognitive Impairment

Award Number: R01NR015452
ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract Our recently completed R01 suggested that processing speed and attention (PS/A) oriented cognitive training (VSOP) produced robust effect on PS/A and working memory, but not in cognitive control or episodic memory, and long-term effects were overall modest. In the proposed R01 renewal, we propose to identify additional attributes to further enhance transferred and long-term effects of PS/A training in older adults with amnestic mild cognitive impairment (MCI) by addressing adaptation capacity that underpins adaptive learning and neuroplasticity. The goal of the stage II double-blinded randomized trial is to test whether adding resonance frequency breathing (RFB) training to VSOP will strengthen multiple contributors to adaptation capacity, particularly the central and peripheral pathways of autonomic nervous system (ANS) flexibility, which will strengthen VSOP training effect on cognitive and brain function and slow the progress of dementia in MCI. Our central hypothesis is that strengthening adaptation capacity, via improving autonomic nervous system (ANS) flexibility, will enhance neuroplasticity and slow progress of dementia in MCI, since adaptation capacity is critical for neuroplasticity of VSOP, but compromised in neurodegenerative process. Older adults with MCI (n = 114) will be randomly assigned to an 8-week combined intervention (RFB+VSOP), VSOP with guided imagery relaxation (IR) control, and a waitlist IR control, with periodical booster training sessions at follow-ups. Mechanistic and distal outcomes include ANS flexibility and multiple markers of dementia progress. Data will be collected across a 14-month period. The two primary aims are to examine long-term effects of the combined intervention on ANS flexibility (Aim 1), as well as the cognitive, behavioral, and functional capacity (Aim 2). The exploratory aim will be to determine the preliminary long-term effect of the combined intervention on neurodegeneration. We consider this a reasonable renewal plan from our completed R01, aiming to identify additional attributes to further enhance transferred and long-term effects of cognitive training in MCI. This will be among the first RCTs to examine a novel, combined intervention targeting adaptation capacity in MCI, with an ultimate goal for slowing neurodegeneration. The proposed work is aligned with NINR strategic plan to advance nursing science, eps. symptoms management (in this case, improving cognitive and functional symptoms in MCI) using a non-pharmacological intervention approach and understanding relevant mechanisms.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $368,973 )
2024	2024	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Nursing Research	000	9	2/8/2024	NON-COMPETING CONTINUATION	$368,973
														Subtotal = $368,973

Issue Date FY: 2023 ( Subtotal = $506,138 )
2023	2023	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Nursing Research	000	8	2/23/2023	NON-COMPETING CONTINUATION	$506,138
														Subtotal = $506,138

Issue Date FY: 2022 ( Subtotal = $518,333 )
2022	2022	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Nursing Research	001	7	4/20/2022	NON-COMPETING CONTINUATION	$51,833
2022	2022	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Nursing Research	000	7	2/9/2022	NON-COMPETING CONTINUATION	$466,500
														Subtotal = $518,333

Issue Date FY: 2021 ( Subtotal = $509,124 )
2021	2021	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Nursing Research	001	6	6/25/2021	NON-COMPETING CONTINUATION	$0
2021	2021	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Nursing Research	000	6	2/26/2021	NON-COMPETING CONTINUATION	$509,124
														Subtotal = $509,124

Issue Date FY: 2020 ( Subtotal = $418,125 )
2020	2020	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Nursing Research	003	5	9/10/2020	COMPETING CONTINUATION	$54,912
2020	2020	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Nursing Research	001	5	5/8/2020	COMPETING CONTINUATION	$418,125
2020	2018	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Nursing Research	000	4	5/1/2020	NON-COMPETING CONTINUATION	$0
2020	2018	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Nursing Research	002	4	9/10/2020	NON-COMPETING CONTINUATION	-$54,912
														Subtotal = $418,125

Issue Date FY: 2018 ( Subtotal = $465,852 )
2018	2018	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Nursing Research	000	4	7/24/2018	NON-COMPETING CONTINUATION	$465,852
														Subtotal = $465,852

Issue Date FY: 2017 ( Subtotal = $502,587 )
2017	2017	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Nursing Research	000	3	7/17/2017	NON-COMPETING CONTINUATION	$502,587
														Subtotal = $502,587

Issue Date FY: 2016 ( Subtotal = $526,294 )
2016	2016	UNIVERSITY OF ROCHESTER	1325 MOUNT HOPE AVE, SUITE 260	ROCHESTER	NY	14642	MONROE	USA	Nursing Research	000	2	7/8/2016	NON-COMPETING CONTINUATION	$526,294
														Subtotal = $526,294

Issue Date FY: 2015 ( Subtotal = $513,459 )
2015	2015	UNIVERSITY OF ROCHESTER	1325 MOUNT HOPE AVE, SUITE 260	ROCHESTER	NY	14642	MONROE	USA	Nursing Research	000	1	9/4/2015	NEW	$513,459
														Subtotal = $513,459

Grand Total All Awards = $4,328,885

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Targeting Autonomic Flexibility to Enhance Cognitive Training Outcomes in Older Adults with Mild Cognitive Impairment

Award Number: R01NR015452

ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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