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Adaptive, Regionally- and Individually-Tailored, AI-Based Intervention to Increase HIV Testing and Prevention in Philadelphia

Award Number: R01MH140783
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2026
PERIOD OF PERFORMANCE END DATE: 05/31/2031

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Adaptive, Regionally- and Individually-Tailored, AI-Based Intervention to Increase HIV Testing and Prevention in Philadelphia - PROJECT SUMMARY This ambitious research project will test the effectiveness and dissemination of a digital intervention to promote home HIV testing and linkage to PrEP (Pre-Exposure Prophylaxis) among Men who have Sex with Men (MSM) in Philadelphia. In alignment with the strategic priorities of the Office of HIV Health in the Philadelphia Department of Public Health (PDPH), the experimental arm will deliver tailored social-media and SMS messages and nudges generated by a local Community Advisory Board (CAB) and Al-driven algorithms. We will randomize MSM participants (N = 1,000) to one of two conditions. The standard of care arm will involve the PhillyKeepOnLoving social marketing campaign that the PDPH is currently implementing and future city campaigns. The primary effectiveness outcome is annual routine HIV testing and PrEP (2 HIV tests at least 4 months apart from one another for HIV-negative participants and PrEP), and secondary effectiveness outcomes are ART uptake and retention, as well as sexual risk behavior. Implementation outcomes include reach, adoption, implementation, and maintenance, and dissemination outcomes include the number of shares and likes of the messages from the campaign. We will also evaluate mediators, including the personal relevance and trustworthiness of the messages, as well as motivation, information, and behavioral skills to seek services. This trial, led by an outstanding team and involving institutions committed to successful HIV prevention, will help to advance the Respond pillar of the Ending the HIV Epidemic (EHE) initiative. Through a novel synergy, the proposed research may transform how future campaigns are conducted to engage participants in HIV prevention leveraging LLMs (Large Language Models) and community engagement.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $812,484 )
2026	2026	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	000	1	7/7/2026	NEW	$812,484
														Subtotal = $812,484

Grand Total All Awards = $812,484

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Adaptive, Regionally- and Individually-Tailored, AI-Based Intervention to Increase HIV Testing and Prevention in Philadelphia

Award Number: R01MH140783

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2026

PERIOD OF PERFORMANCE END DATE: 05/31/2031

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