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Investigating 24-Hour Patterns of Sleep and Negative Affect among Individuals with Recurrent Binge Eating Behavior

Award Number: R01MH139617
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/20/2025
PERIOD OF PERFORMANCE END DATE: 01/31/2030

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Investigating 24-Hour Patterns of Sleep and Negative Affect among Individuals with Recurrent Binge Eating Behavior - PROJECT SUMMARY/ABSTRACT Binge eating (i.e., the consumption of an unusually large amount of food in a discrete period of time accompanied by loss of control) is a transdiagnostic eating disorder behavior with significant implications for health and functioning. However, treatment outcomes for binge eating psychopathology (e.g., binge eating disorder) are suboptimal, warranting consideration of novel factors which may increase risk for or maintenance of binge eating. Sleep disturbance has been observed among individuals with binge eating psychopathology, and multiple aspects of sleep have been implicated in binge eating behavior, including sleep duration, variability, and daytime napping. The proposed study builds upon existing knowledge by 1) identifying 24-hour patterns of sleep that signal individual vulnerability for binge eating, and 2) disentangling the bidirectional link between sleep and binge eating at a more granular, daily level, integrating aspects of two theoretical models of eating disorders focused on circadian factors and negative affect. To achieve study aims, the proposed project will recruit 230 adults with recurrent binge eating behavior who will complete a remote clinical screening and a fourteen-day, intensive longitudinal assessment of sleep, affect, and disordered eating behaviors using wrist actigraphy to estimate sleep characteristics and naps and ecological momentary assessment to measure eating disorder behaviors and negative affect at seven signals throughout each day. These data will be used to identify 24-hour patterns of sleep that signal individual vulnerability for binge eating behavior by investigating the interplay of sleep duration mean and variability and nap patterns as they relate to overall binge eating behavior. Improved recognition of person-level biobehavioral patterns that predict vulnerability for binge eating can help to better identify individuals for whom sleep promotion adjunctive therapies may be considered to promote more successful ED treatment outcomes. In addition, we will disentangle the bidirectional link between sleep and binge eating at the daily level, examining the influence of negative affect, naps, and binge timing on this relationship. Improved understanding of the temporal dynamics of these complex relationships can inform improvements to existing momentary and traditional treatments for binge eating by providing novel, modifiable targets for intervention.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $624,970 )
2026	2026	NORTH DAKOTA STATE UNIVERSITY	1340 ADMINISTRATION AVE	FARGO	ND	58105	CASS	USA	Mental Health Research Grants	000	2	1/22/2026	NON-COMPETING CONTINUATION	$624,970
														Subtotal = $624,970

Issue Date FY: 2025 ( Subtotal = $669,049 )
2025	2025	NORTH DAKOTA STATE UNIVERSITY	1340 ADMINISTRATION AVE	FARGO	ND	58105	CASS	USA	Mental Health Research Grants	000	1	3/20/2025	NEW	$669,049
														Subtotal = $669,049

Grand Total All Awards = $1,294,019

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Investigating 24-Hour Patterns of Sleep and Negative Affect among Individuals with Recurrent Binge Eating Behavior

Award Number: R01MH139617

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/20/2025

PERIOD OF PERFORMANCE END DATE: 01/31/2030

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