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Validation of electrophysiological biomarkers associated with performance in a preclinical assay of sustained attention

Award Number: R01MH137057
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/10/2024
PERIOD OF PERFORMANCE END DATE: 03/31/2029

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Validation of electrophysiological biomarkers associated with performance in a preclinical assay of sustained attention - PROJECT SUMMARY Sustained attention, the ability to focus on an activity or stimulus over time, is impaired in many brain disorders. Targeting attentional deficits for treatment is critical because these symptoms are negatively correlated with functional outcome and quality of life. Continuous performance tests (CPTs) have been designed to measure sustained attention in multiple species. Similar neural circuits are engaged in both humans and model organisms during CPT performance, supporting their use in translational studies that screen for novel therapeutics. The prelimbic cortex (PrL), is involved in both conflict detection and allocation of attention to cues before orientation, important components in go/no-go tasks like CPTs. Electroencephalogram (EEG) studies in humans show that neural activity in the dorsal anterior cingulate cortex (dACC), which shows functional and anatomical analogy to the rodent PrL, is correlated with task engagement and performance in the CPT. In this application, we optimize the rCPT to determine the effect of target percentage on the time-on-task vigilance decrement. We then evaluate the optimized CPT paradigm by assessing the impact of amphetamine, a known enhancer of performance, on the electrophysiological correlates of behavior. Finally, we mechanistically test the role of neural activity in the PrL-LC circuit in controlling behavioral performance and electrophysiological correlates in the optimized rCPT.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $762,036 )
2025	2025	THE LIEBER INSTITUTE	855 N WOLFE ST STE 300	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Mental Health Research Grants	000	2	4/10/2025	NON-COMPETING CONTINUATION	$647,730
2025	2025	THE LIEBER INSTITUTE	855 N WOLFE ST STE 300	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Mental Health Research Grants	001	2	9/22/2025	NON-COMPETING CONTINUATION	$114,306
														Subtotal = $762,036

Issue Date FY: 2024 ( Subtotal = $753,016 )
2024	2024	THE LIEBER INSTITUTE	855 N WOLFE ST STE 300	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Mental Health Research Grants	000	1	7/10/2024	NEW	$753,016
														Subtotal = $753,016

Grand Total All Awards = $1,515,052

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Validation of electrophysiological biomarkers associated with performance in a preclinical assay of sustained attention

Award Number: R01MH137057

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/10/2024

PERIOD OF PERFORMANCE END DATE: 03/31/2029

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