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Family Psychoeducation for Adults with Psychotic Disorders in Tanzania (KUPAA trial)

Award Number: R01MH136145
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2024
PERIOD OF PERFORMANCE END DATE: 03/31/2029

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Family Psychoeducation for Adults with Psychotic Disorders in Tanzania (KUPAA trial) - PROJECT ABSTRACT Family psychoeducation for adults living with psychotic disorders in Tanzania (KUPAA Trial) Psychotic disorders such as schizophrenia contribute to the global burden of disease in low- and middle- income countries (LMICs) yet mental health services have been severely neglected. Family Psychoeducation is an evidence-based practice from high-income countries that could have a significant impact in settings such as Africa and other regions worldwide where resources are limited and family involvement in treatment is fundamental. In response to PAR-21-130, this R01 will evaluate the impact of a culturally tailored version of family psychoeducation called KUPAA (meaning “to soar” in Swahili) that is group-based and family-involved in a low-income country context. The KUPAA intervention was recently pilot tested with adults living schizophrenia-spectrum disorders and their families in Tanzania. The proposed hybrid effectiveness- implementation clinical trial would individually randomize patient-caregiver pairs to either the group-based intervention or the standard of care across 14 health facilities in four regions of Tanzania. The overall objective is to improve recovery outcomes for individuals with schizophrenia-spectrum disorders. Aim #1: Determine the effectiveness of KUPAA vs. standard of care for an outpatient population (n=432) by reducing disability and improving quality of life (primary outcomes); and reducing hospitalizations and reducing perceived family burden for caregivers (secondary outcomes) among matched patient-caregiver dyads. Aim #2: Examine the mechanisms of change underlying KUPAA as a group-based, family-involved intervention. Aim #3: Evaluate implementation outcomes guided by the Consolidated Framework for Implementation Research (CFIR) via mixed methods (n=122 semi-structured interviews, observational data, cost data). This project is a collaboration between the University of North Carolina at Chapel Hill, Duke University and four Tanzanian institutions: Muhimbili University of Health and Allied Sciences in Dar es Salaam, Mbeya Zonal Referral Hospital in Mbeya, Mirembe National Mental Health Hospital in Dodoma, and Kilimanjaro Christian Medical University College in Moshi. This proposal aligns with the NIMH cross-cutting global mental health theme and will contribute to NIMH’s goal of advancing mental health services to strengthen public health by providing insights on an adapted evidence-based practice designed for lower-resource settings that could also inform domestic implementation strategies for scaling family psychoeducation in the U.S.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $682,139 )
2025	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Mental Health Research Grants	000	2	3/14/2025	NON-COMPETING CONTINUATION	$682,139
														Subtotal = $682,139

Issue Date FY: 2024 ( Subtotal = $729,802 )
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Mental Health Research Grants	000	1	5/16/2024	NEW	$729,802
														Subtotal = $729,802

Grand Total All Awards = $1,411,941

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Family Psychoeducation for Adults with Psychotic Disorders in Tanzania (KUPAA trial)

Award Number: R01MH136145

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2024

PERIOD OF PERFORMANCE END DATE: 03/31/2029

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