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Cellular resolution multi-omics of white matter tracts in developing human and non-human primate brain for cell atlases

Award Number: R01MH134809
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2024
PERIOD OF PERFORMANCE END DATE: 02/28/2027

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Cellular resolution multi-omics of white matter tracts in developing human and non-human primate brain for cell atlases - Project Summary/Abstract The molecular evolution underlying cell type diversity and function has facilitated the increased cognitive capacity of humans. While significant progress has been made to uncover cell type specific gene expression programs in the brains of rodents, only a modest amount of progress has been made in human brains. Moreover, the majority of the existing cell type genomic datasets focus on gray matter. Our recent work has identified important human-specific gene expression patterns relevant to non-neurons, especially oligodendrocytes. Human brain imaging studies in disorders such as autism spectrum disorders and schizophrenia have identified alterations in white matter tracts that are primarily comprised of oligodendrocytes. We therefore propose to profile white matter tracts that are anatomically comparable across primates: pyramidal tract, optic chiasm, cerebellar white matter, and corpus callosum. Because oligodendrocyte maturation varies between gray and white matter, we will profile tissue across development. This comparative cell type profiling between human and non-human primate brain will provide spatially defined epigenomic and transcriptomic data through the following four Aims: 1) Profile single cell level transcriptional maps and chromatin states of white matter tracts and functionally associated gray matter in human brain across development; 2) Profile single cell level transcriptional maps and chromatin states of white matter tracts and functionally associated gray matter across development in two non-human primates: rhesus macaque and the common marmoset; 3) Profile single cell level transcriptional maps and chromatin states of white matter tracts and functionally associated gray matter in additional tissue from adult great ape and monkey brains; and 4) Validate observed differences in white matter composition at the cell type level in human and non- human primates. Together, these aims will molecularly define understudied cell types from human and non- human primate brains.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,361,992 )
2025	2025	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Mental Health Research Grants	001	2	4/29/2025	NON-COMPETING CONTINUATION	$1,331,545
2025	2025	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Mental Health Research Grants	000	1	1/27/2025	SUPPLEMENT FOR EXPANSION	$30,447
														Subtotal = $1,361,992

Issue Date FY: 2024 ( Subtotal = $1,570,076 )
2024	2024	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Mental Health Research Grants	000	1	5/2/2024	NEW	$1,570,076
														Subtotal = $1,570,076

Grand Total All Awards = $2,932,068

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Cellular resolution multi-omics of white matter tracts in developing human and non-human primate brain for cell atlases

Award Number: R01MH134809

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2024

PERIOD OF PERFORMANCE END DATE: 02/28/2027

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