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The Vascular Axis in Schizophrenia Brain-Body Aging

Award Number: R01MH133812
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/08/2024
PERIOD OF PERFORMANCE END DATE: 12/31/2028

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The Vascular Axis in Schizophrenia Brain-Body Aging - Project Summary People with schizophrenia spectrum disorders have a shorter lifespan and higher morbidity and mortality than the general population, with cardiovascular conditions on top of the leading causes. Brain imaging research has revealed accelerated age-related brain changes in patients with schizophrenia spectrum disorders. However, neuroimaging studies of schizophrenia are typically brain-focused without system-level investigations on the risk factors. The causes of the exaggerated body and brain aging in schizophrenia is still largely unexplained, making it difficult to provide more effective screening and management for the devastating medical consequences for people suffering from schizophrenia. There are likely missing opportunities as vascular contributions to brain, especially white matter health, are well established in the general population. The goal of the current proposal is to utilize the standard but state-of-the-art vascular biology measures, combined with cutting-edge brain imaging that is informative of the underlying mechanisms, to study the potential vascular contributions to the accelerated age-related brain and cardiovascular diseases in schizophrenia. We will compare various vascular biomarkers and between vascular and stress factors, to identify the key body-brain paths that may explain the reason that schizophrenia spectrum disorders are associated with such high age-related medical and brain burden. The study may provide insights into the timing and mode for more effective screening, prevention and treatment effort.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $764,880 )
2026	2026	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON	7000 FANNIN ST FL 9	HOUSTON	TX	77030	HARRIS	USA	Mental Health Research Grants	000	3	4/13/2026	NON-COMPETING CONTINUATION	$764,880
														Subtotal = $764,880

Issue Date FY: 2025 ( Subtotal = $651,937 )
2025	2025	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON	7000 FANNIN ST FL 9	HOUSTON	TX	77030	HARRIS	USA	Mental Health Research Grants	000	2	2/13/2025	NON-COMPETING CONTINUATION	$651,937
														Subtotal = $651,937

Issue Date FY: 2024 ( Subtotal = $790,718 )
2024	2024	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON	7000 FANNIN ST FL 9	HOUSTON	TX	77030	HARRIS	USA	Mental Health Research Grants	001	1	4/30/2024	NEW	$76,118
2024	2024	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON	7000 FANNIN ST FL 9	HOUSTON	TX	77030	HARRIS	USA	Mental Health Research Grants	000	1	3/8/2024	NEW	$714,600
														Subtotal = $790,718

Grand Total All Awards = $2,207,535

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The Vascular Axis in Schizophrenia Brain-Body Aging

Award Number: R01MH133812

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/08/2024

PERIOD OF PERFORMANCE END DATE: 12/31/2028

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