Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

A tale of two cities: Understanding geographic differences by region and rurality in HIV care outcomes in the U.S.

Award Number: R01MH131542
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/08/2022
PERIOD OF PERFORMANCE END DATE: 05/31/2027

Group Awards By:

View Award Description

A tale of two cities: Understanding geographic differences by region and rurality in HIV care outcomes in the U.S. - The U.S. initiative of Ending the HIV Epidemic (EHE) has fallen short of its goals, and geographic differences in HIV care outcomes have only widened in the last decade. For example, here are significant differences in HIV care outcomes, such as viral suppression and hospitalization rates, among people living with HIV (PLWH) between the Western and Southern regions of the U.S., as well as among urban centers and rural areas. These geographic differences are also observed in other chronic diseases, yet, PLWH appear to be at higher risk of poorer health outcomes than persons not living with HIV (PNLWH), especially in rural areas. These geographic differences are likely largely driven by underlying factors in our health systems, such as access to healthcare, providers, and specialized care centers in rural areas—an understanding of these pathways that elucidate these differences is urgently needed to develop the next generation of HIV interventions operating at the health systems levels, and ever more now in the context of compounding chronic diseases affecting PLWH. The National Clinical Cohort Collaborative (N3C) leverages real-world, national data and presents an unprecedented opportunity to inform the NIH priority aims to understand the factors that affect both HIV and other chronic conditions. N3C is the largest electronic health record (EHR) repository in U.S. history (>20M patients), contains both unparalleled individual-level granular clinical and historical data, and represents the largest U.S. cohort of PLWH with their HIV and other chronic conditions outcomes data (>120K), allowing us to evaluate the bi-directional impact of existing HIV infection and other chronic diseases outcomes. Furthermore, individual-level data in the N3C are uniquely positioned to merge publicly available datasets that measure area-level health systems factors. Our central hypothesis is that the observed geographic differences in HIV and other chronic diseases occur in a larger context of individuals embedded in health systems with very significant differences across the U.S., between urban areas as well as between urban and nearby rural areas. Understanding these forces, allows us to determine the next generation of HIV interventions. Our three aims respond to the NIH call using data science, rigorous and reproducible machine and statistical learning, and multi-level mediation and epidemic modeling. The goal of Aim 1 (HIV outcomes) is to identify multilevel, geographic and health systems differences in HIV outcomes (e.g., viral suppression and hospitalization) over the recent years. The goal of Aim 2 (chronic diseases outcomes) is to understand the independent and aggregated impact of geographic differences and clinical characteristics on health outcomes (2a) and quantify the differential impact of HIV on other chronic diseases outcomes at the U.S. population level by geography (2b). The goal of Aim 3 (HIV epidemic modeling) is to quantify the impact of other chronic diseases on HIV care and prevention outcomes by geography at the population-level for the national EHE initiative’s priority jurisdictions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $566,463 )
2026	2026	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Mental Health Research Grants	000	6	6/18/2026	NON-COMPETING CONTINUATION	$566,463
														Subtotal = $566,463

Issue Date FY: 2025 ( Subtotal = $571,567 )
2025	2025	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Mental Health Research Grants	001	5	8/13/2025	NON-COMPETING CONTINUATION	$571,567
2025	2023	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Mental Health Research Grants	000	2	12/19/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $571,567

Issue Date FY: 2024 ( Subtotal = $548,386 )
2024	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Mental Health Research Grants	002	4	5/21/2024	NON-COMPETING CONTINUATION	$548,386
2024	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Mental Health Research Grants	003	4	8/21/2024	NON-COMPETING CONTINUATION	$0
2024	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Mental Health Research Grants	001	3	1/4/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$645,647
2024	2023	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Mental Health Research Grants	000	2	1/4/2024	NON-COMPETING CONTINUATION	-$645,647
														Subtotal = $548,386

Issue Date FY: 2023 ( Subtotal = $656,972 )
2023	2023	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Mental Health Research Grants	000	2	6/22/2023	NON-COMPETING CONTINUATION	$656,972
														Subtotal = $656,972

Issue Date FY: 2022 ( Subtotal = $722,272 )
2022	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Mental Health Research Grants	001	1	7/20/2022	NEW	$0
2022	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Mental Health Research Grants	000	1	7/8/2022	NEW	$722,272
														Subtotal = $722,272

Grand Total All Awards = $3,065,660

Top

All Categories

About

Search

Reports

Data Submission

Award Information

A tale of two cities: Understanding geographic differences by region and rurality in HIV care outcomes in the U.S.

Award Number: R01MH131542

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/08/2022

PERIOD OF PERFORMANCE END DATE: 05/31/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer