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Predicting psychosis risk in youth using a novel structural neuroimaging score that measures deviation from normative development. Can we bring it to communities using portable, low-field MRI?

Award Number: R01MH129636
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2022
PERIOD OF PERFORMANCE END DATE: 02/28/2027

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Predicting psychosis risk in youth using a novel structural neuroimaging score that measures deviation from normative development. Can we bring it to communities using portable, low-field MRI? - Project Summary/Abstract Converging lines of evidence support the hypothesis that deviations from typical brain structure development take place prior to psychosis onset, while ‘big data’ neuroimaging studies of adults with psychosis find subtle, widespread gray matter disruptions in the brain. In this proposal, we will synergize knowledge about normative structural neurodevelopment and findings of structural brain aberrations in adults with psychosis to develop cost-effective brain-based markers of psychosis risk in youth. To improve identification of those at greatest risk, we leverage results from large-scale structural neuroimaging studies of psychosis to create a ‘Psychosis Neuroimaging Score’, a cumulative summary score that reflects one’s psychosis liability. We first aim to transport the Psychosis Neuroimaging Score to youth by incorporating crucial aspects of structural brain development. In Aim 1, we will characterize the normative developmental trajectory of the Psychosis Neuroimaging Score by harmonizing many archival datasets of normative development (N>5,000, 2-30 years old). We will then evaluate how greater age-associated deviation from the aggregate Psychosis Neuroimaging Score differentiates youth with psychosis spectrum symptoms from typically developing youth in the Philadelphia Neurodevelopmental Cohort (N=1209, 10-22 years old). In Aim 2, we plan to examine how greater age-associated deviation from the aggregate Psychosis Neuroimaging Score predicts distinct developmental trajectories associated with psychotic-like experiences in youth from the Adolescent Brain and Cognitive Development Study (N=11,875). We will also assess the extent to which known psychosis risk factors (e.g., family history of psychosis, obstetric complications, trauma) contribute to characterization of these trajectories. Finally, in Aim 3, we propose to use measurement-in-error modeling to establish a functional relationship between Psychosis Neuroimaging scores generated from 3T MRI scans and those generated using low-field MRI scans in a community sample of youth. Results from this study will allow us to create more affordable, clinically accessible biological indicators of severe psychopathology, ultimately improving identification of young people at greatest risk and allowing earlier, more effective interventions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $749,537 )
2026	2026	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	000	5	2/24/2026	NON-COMPETING CONTINUATION	$749,537
														Subtotal = $749,537

Issue Date FY: 2025 ( Subtotal = $776,080 )
2025	2025	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	000	4	3/14/2025	NON-COMPETING CONTINUATION	$659,667
2025	2025	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	001	4	9/22/2025	NON-COMPETING CONTINUATION	$116,413
														Subtotal = $776,080

Issue Date FY: 2024 ( Subtotal = $773,425 )
2024	2024	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	000	3	2/16/2024	NON-COMPETING CONTINUATION	$696,083
2024	2024	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	001	3	8/14/2024	NON-COMPETING CONTINUATION	$77,342
														Subtotal = $773,425

Issue Date FY: 2023 ( Subtotal = $764,137 )
2023	2023	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	000	2	3/6/2023	NON-COMPETING CONTINUATION	$764,137
														Subtotal = $764,137

Issue Date FY: 2022 ( Subtotal = $753,430 )
2022	2022	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	000	1	4/27/2022	NEW	$753,430
														Subtotal = $753,430

Grand Total All Awards = $3,816,609

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Predicting psychosis risk in youth using a novel structural neuroimaging score that measures deviation from normative development. Can we bring it to communities using portable, low-field MRI?

Award Number: R01MH129636

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2022

PERIOD OF PERFORMANCE END DATE: 02/28/2027

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