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Neurostimulation Enhanced Cognitive Restructuring for Transdiagnostic Emotional Dysregulation: A Component Analysis

Award Number: R01MH129302
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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This application proposes the addition of data collection and hypotheses for the parent R01 in support of the training of a very promising graduate student from an under-represented background. Using data from a completed pilot study in individuals with emotion dysregulation, our team has shown that task-based functional activity and connectivity in the insula are associated with induction of negative emotion, utilization of emotion regulation skills, and emotion dysregulation severity. In a comparison group of non-clinical participants, utilization of emotion regulation skills was associated with increased functional connectivity strength between the insula and the mPFC, a default mode network node. These findings suggest that dynamics between the salience and other large-scale prefrontal networks differ between emotionally dysregulated and non-clinical participants. Therefore, the supplement plans to examine the hypothesis that cortico-insular connections are critically involved in emotion dysregulation and may be a mechanism for the therapeutic response to neuromodulatory perturbation. Ms. Gerlus is planning to learn and employ a connectomic approach to determine how cortico-insular connectivity is related to emotion dysregulation and affected by brain stimulation. The skills and training proposed would allow her to establish the foundation for a physician-scientist career at the intersection of psychiatry and neuroscience and would serve as the basis for her dissertation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $775,774 )
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	000	2	11/2/2023	NON-COMPETING CONTINUATION	$711,699
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	001	2	3/8/2024	SUPPLEMENT FOR EXPANSION	$64,075
														Subtotal = $775,774

Issue Date FY: 2023 ( Subtotal = $793,992 )
2023	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	000	1	12/16/2022	NEW	$793,992
														Subtotal = $793,992

Grand Total All Awards = $1,569,766

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Neurostimulation Enhanced Cognitive Restructuring for Transdiagnostic Emotional Dysregulation: A Component Analysis

Award Number: R01MH129302

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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