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Effects of pandemic-related disruption to social connectedness on the brain and emotional wellbeing in adolescents

Award Number: R01MH128959
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2022
PERIOD OF PERFORMANCE END DATE: 12/31/2026

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Effects of pandemic-related disruption to social connectedness on the brain and emotional wellbeing in adolescents - PROJECT SUMMARY The social reorientation of the adolescent period is accompanied by extensive neurodevelopmental changes. To understand the neurodevelopmental networks underlying responses to social environments and how social connectedness influences neurodevelopment, manipulation of social connectedness among youth is required, which is impossible in a large-scale setting. In 2020, the COVID pandemic happened, in the midst of longitudinal follow-up of participants in the Adolescent Brain Cognition Development (ABCD) study, inducing dramatic changes to social connectedness in adolescents in the study. Because the levels of stay-at-home restriction were imposed agnostically to participants' pre-pandemic status, this becomes a naturally occurred experiment on social connectedness among adolescents. Together with the comprehensive pre-pandemic assessments, longitudinal follow-up with surveys and geolocation data collected during the pandemic period, and the resumption of multimodal imaging scans and regular assessments restarting during, and continuing after 2021, we can use longitudinal ABCD data to critically examine the relationships between social connectedness and neurodevelopment among youth. In particular, we propose to use ABCD data to investigate 1) the neurobiological and social factors (pre-pandemic) that render an individual more sensitive to the disruption of social connectedness (peri-pandemic), contributing to emotional turmoil during and beyond the pandemic period; 2) the modulating factors that buffer/exacerbate the emotion responses during a prolonged period of social disruption (peri-pandemic); and 3) the extent of deviation in neurodevelopment after the pandemic (post-pandemic) in relation to the varying levels of social disruptions in ABCD participants during the pandemic. We will pursue these aims by utilizing a novel combination of methods from high-dimensional data analysis and population inference, innovatively tailoring the analytic strategies to avoid potential biases and spurious associations. The proposed research is of high public health interest because the identified neurobiological mechanisms underlying the emotional responses toward the disruption of social connectedness will provide novel insights for therapeutics and public health interventions in adolescents, due to the population-informed ABCD sample. By sharing our developed tools and derived social variables for this research program, we will impact the field immediately. These novel analytic tools enable us and others to more deeply investigate with ABCD data, neurodevelopmental processes specifically related to social connectedness. Results can inform peri- and post-pandemic clinical practice to regain and improve mental health in youth.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $657,000 )
2025	2025	LAUREATE INSTITUTE FOR BRAIN RESEARCH, LLC	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Mental Health Research Grants	000	4	12/4/2024	NON-COMPETING CONTINUATION	$657,000
														Subtotal = $657,000

Issue Date FY: 2024 ( Subtotal = $790,302 )
2024	2024	LAUREATE INSTITUTE FOR BRAIN RESEARCH, LLC	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Mental Health Research Grants	004	3	7/18/2024	NON-COMPETING CONTINUATION	$79,029
2024	2024	LAUREATE INSTITUTE FOR BRAIN RESEARCH, LLC	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Mental Health Research Grants	000	3	12/12/2023	NON-COMPETING CONTINUATION	$711,273
2024	2024	LAUREATE INSTITUTE FOR BRAIN RESEARCH, LLC	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Mental Health Research Grants	003	3	7/16/2024	NON-COMPETING CONTINUATION	$0
2024	2023	LAUREATE INSTITUTE FOR BRAIN RESEARCH, LLC	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Mental Health Research Grants	002	2	12/13/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$847,969
2024	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	001	1	12/13/2023	NEW	-$847,969
														Subtotal = $790,302

Issue Date FY: 2023 ( Subtotal = $852,594 )
2023	2023	LAUREATE INSTITUTE FOR BRAIN RESEARCH	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Mental Health Research Grants	001	2	1/24/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$852,594
2023	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	000	1	1/24/2023	NEW	$0
														Subtotal = $852,594

Issue Date FY: 2022 ( Subtotal = $847,969 )
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	000	1	2/24/2022	NEW	$847,969
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	001	1	5/10/2022	NEW	$0
														Subtotal = $847,969

Grand Total All Awards = $3,147,865

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Effects of pandemic-related disruption to social connectedness on the brain and emotional wellbeing in adolescents

Award Number: R01MH128959

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2022

PERIOD OF PERFORMANCE END DATE: 12/31/2026

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