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Prenatal to Preschool: elucidating the impact of stressors in two cohorts of mothers, fathers/secondary caregivers and their developing young children

Award Number: R01MH128593
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/06/2022
PERIOD OF PERFORMANCE END DATE: 05/31/2027

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Prenatal to Preschool: elucidating the impact of stressors in two cohorts of mothers, fathers/secondary caregivers and their developing young children - Stressors that significantly impact the health and well-being of adults and children, including individual and neighborhood, factors, can also adversely impact parenting relationships and optimal child development. This is of particular importance for families with very young children (those under the age of 5) considering the criticality of the peripartum period on early neurodevelopment. The literature suggests that early maternal mental health problems can have lasting, and negative effects on parent-child interactions, infant/child development, and mental and behavioral health of both women and children. Although there is increasing knowledge of the impact of these known threats on child development beginning prenatally, mechanisms underpinning these transmissions are still being investigated. Identifying women disproportionately impacted by health crises during the peripartum period, provides an opportunity to understand the developing child’s environment, mother’s mental health, and parenting experience, with the long-term goal of improving infant/young child neurodevelopmental and behavioral health outcomes by ensuring appropriate, precise, timely, personalized interventions. The proposed multi-methods project consists of three aims that will longitudinally examine child neurodevelopmental outcomes by early identification of Black and White mothers with mental health challenges. The first aim implements extensive screening of postpartum Black and Whtie mothers using a battery of questionnaires and gold-standard clinical psychiatric interviews to identify mothers currently experiencing distress and psychopathology, as well as determining resilience factors. Fathers/secondary caregivers will also complete similar questionnaires assessing levels of support. The second aim identifies parental concern about their child’s development and behavioral health at two developmental time points (24 and 48-months) while simultaneously assessing mother/child interactions on a series of dyadic (parent/child) tasks. The final aim consists of qualitative interviews with a sub-sample of Black women characterizing the impact of a major health crisis on their mental health, parenting practices, perceptions of their child’s early development, and trust in the healthcare system. The overarching goal of this application is to deeply characterize the experiences of women and children impacted by a health crisis filling the gap in the research by identifying specific maternal health, support, and well-being and neighborhood factors-including access to health-care, daily needs and mechanisms that critically influence early child development and behavioral health, allowing for future precision intervention development.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $520,787 )
2026	2026	THE CHILDREN'S HOSPITAL OF PHILADELPHIA	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	000	5	9/17/2026	NON-COMPETING CONTINUATION	$520,787
														Subtotal = $520,787

Issue Date FY: 2025 ( Subtotal = $554,805 )
2025	2025	THE CHILDREN'S HOSPITAL OF PHILADELPHIA	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	000	4	9/24/2025	NON-COMPETING CONTINUATION	$554,805
														Subtotal = $554,805

Issue Date FY: 2024 ( Subtotal = $706,010 )
2024	2024	THE CHILDREN'S HOSPITAL OF PHILADELPHIA	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	000	3	5/16/2024	NON-COMPETING CONTINUATION	$706,010
2024	2024	THE CHILDREN'S HOSPITAL OF PHILADELPHIA	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	001	3	8/21/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $706,010

Issue Date FY: 2023 ( Subtotal = $571,247 )
2023	2023	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	000	2	6/2/2023	NON-COMPETING CONTINUATION	$571,247
														Subtotal = $571,247

Issue Date FY: 2022 ( Subtotal = $834,125 )
2022	2022	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	000	1	7/6/2022	NEW	$834,125
														Subtotal = $834,125

Grand Total All Awards = $3,186,974

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Prenatal to Preschool: elucidating the impact of stressors in two cohorts of mothers, fathers/secondary caregivers and their developing young children

Award Number: R01MH128593

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/06/2022

PERIOD OF PERFORMANCE END DATE: 05/31/2027

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