Tuesday, September 16, 2025 9/16/2025

EMERGE: Ecological Momentary Evaluation of Responses to Gain/Loss and Emotions

Award Number: R01MH128546
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/15/2022
PERIOD OF PERFORMANCE END DATE: 12/31/2026

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EMERGE: Ecological Momentary Evaluation of Responses to Gain/Loss and Emotions - PROJECT SUMMARY/ABSTRACT Suicide is a leading cause of death worldwide, accounting for nearly 800,000 deaths each year.1,2 Suicide rates continue to increase in the U.S.3 Most research on suicide risk factors has identified static, dispositional factors.4 These data inform us about groups at actuarial risk, but do very little to predict with useful precision when people will have suicidal thoughts or act on suicide thoughts. Thus, there is an urgent need to identify proximal risk factors for suicide risk. Two of the leading factors distally associated with increased suicide risk are dysfunctional emotional responses5 and decision-making deficits.6 Suicidal individuals have poorer reinforcement learning,6,7 demonstrating impaired ability to learn and modify behavior in response to reward and punishment. Individuals at high risk for suicide (i.e., borderline personality disorder) also show difficulties learning from punishment and reward,8,9 and the PI’s data show that negative emotions uniquely impair learning in such high-risk populations relative to healthy and clinical controls.10 It is necessary to understand the interactive effects of emotion and reinforcement learning as factors elevating near-term risk for suicidal thoughts and behaviors. Therefore, the proposed study examines both emotional and cognitive processes associated with suicidal thoughts and behaviors among 170 patients with a range of suicidal risk recently treated in an emergency department for a suicidal crisis. Using innovative ecological momentary assessment methods (EMA), the proposed study will examine behavioral measures of reinforcement learning and both physiological and subjective measures of momentary emotions. Aim 1 identifies the main and interactive effects of emotional responses, reinforcement learning, and emotion-related decrements in learning on recent suicidal thoughts and behaviors among suicidal patients recently seen in the emergency department. Aim 2 examines how emotions and learning interact to predict momentary suicidal thoughts and behaviors over four weeks. Aim 3 tests emotion- related decrements in learning as prospective predictors of future suicide risk over a six-month follow-up. The research team (PI: Dixon-Gordon, Co-Is: Ammerman, Boudreaux, Rathlev; Consultants: Hackel; Collaborator: Laws) has access to world-class expertise, with extensive experience recruiting suicidal participants from medical settings, EMA, computational modeling, and experimental psychopathology. The most important challenge facing suicide prevention today is unraveling the complex emotional and cognitive proximal drivers that transform nascent suicide risk into action. Combining state-of-the-art behavioral measures and EMA, we will tease apart the complex longitudinal relations between dysfunctional emotional responses, reduced capacity to learn from reward and punishment, and fluctuations in suicidal thoughts and behaviors. Given the high societal costs of suicide, this work has important health significance. Findings will inform the development of treatments that target emotion dysfunction and learning in samples at-risk for suicide.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $447,575 )
2025	2025	UNIVERSITY OF MASSACHUSETTS	101 COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Mental Health Research Grants	001	4	9/3/2025	NON-COMPETING CONTINUATION	$67,138
2025	2025	UNIVERSITY OF MASSACHUSETTS	101 COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Mental Health Research Grants	000	4	12/20/2024	NON-COMPETING CONTINUATION	$380,437
														Subtotal = $447,575

Issue Date FY: 2024 ( Subtotal = $434,883 )
2024	2024	UNIVERSITY OF MASSACHUSETTS	101 COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Mental Health Research Grants	001	3	7/16/2024	NON-COMPETING CONTINUATION	$38,418
2024	2024	UNIVERSITY OF MASSACHUSETTS	101 COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Mental Health Research Grants	002	3	8/8/2024	SUPPLEMENT FOR EXPANSION	$50,705
2024	2024	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Mental Health Research Grants	000	3	1/24/2024	NON-COMPETING CONTINUATION	$345,760
														Subtotal = $434,883

Issue Date FY: 2023 ( Subtotal = $384,816 )
2023	2023	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Mental Health Research Grants	000	2	1/30/2023	NON-COMPETING CONTINUATION	$384,816
														Subtotal = $384,816

Issue Date FY: 2022 ( Subtotal = $430,738 )
2022	2022	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Mental Health Research Grants	000	1	2/15/2022	NEW	$430,738
														Subtotal = $430,738

Grand Total All Awards = $1,698,012

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EMERGE: Ecological Momentary Evaluation of Responses to Gain/Loss and Emotions

Award Number: R01MH128546

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/15/2022

PERIOD OF PERFORMANCE END DATE: 12/31/2026

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