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Proteomic and Functional Analysis of Presynaptic Physiology and Plasticity

Award Number: R01MH126954
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/10/2021
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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Proteomic and Functional Analysis of Presynaptic Physiology and Plasticity - ABSTRACT The molecular mechanisms of plasticity within the presynapse and its role in behaviors such as learning and memory are still poorly understood, mainly due to a lack of knowledge of the signaling molecules of the presynaptic cytomatrix and tools to spatially and temporally manipulate presynaptic plasticity. This gap in knowledge is a fundamental barrier to the field. In this project, we will develop and utilize innovative proteomic, genome editing, and optogenetic approaches to solve these problems, revealing the proteins and inner workings of the cytomatrix of presynapses from distinct neuronal cell types and their roles in learning and memory. We anticipate these data will provide a new and unparalleled molecular framework for future studies on presynaptic physiology as well as insights into how forms of presynaptic plasticity modulate behavior.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $503,562 )
2025	2025	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	000	5	3/21/2025	NON-COMPETING CONTINUATION	$503,562
														Subtotal = $503,562

Issue Date FY: 2024 ( Subtotal = $592,425 )
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	001	4	8/15/2024	NON-COMPETING CONTINUATION	$59,242
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	000	4	3/11/2024	NON-COMPETING CONTINUATION	$533,183
														Subtotal = $592,425

Issue Date FY: 2023 ( Subtotal = $513,394 )
2023	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	000	3	3/3/2023	NON-COMPETING CONTINUATION	$513,394
														Subtotal = $513,394

Issue Date FY: 2022 ( Subtotal = $540,836 )
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Mental Health Research Grants	001	2	6/21/2022	NON-COMPETING CONTINUATION	$54,085
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Mental Health Research Grants	000	2	3/14/2022	NON-COMPETING CONTINUATION	$486,751
														Subtotal = $540,836

Issue Date FY: 2021 ( Subtotal = $616,145 )
2021	2021	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Mental Health Research Grants	000	1	5/10/2021	NEW	$616,145
														Subtotal = $616,145

Grand Total All Awards = $2,766,362

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Proteomic and Functional Analysis of Presynaptic Physiology and Plasticity

Award Number: R01MH126954

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/10/2021

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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