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SCH: INT: Collaborative Research: Context-Adaptive Multimodal Informatics for Psychiatric Discharge Planning

Award Number: R01MH125740
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/15/2021
PERIOD OF PERFORMANCE END DATE: 02/28/2025

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SCH: INT: Collaborative Research: Context-Adaptive Multimodal Informatics for Psychiatric Discharge Planning - Which psychiatric symptoms and behaviors are the most important to assess and manage during critical points in psychiatric healthcare, such as the time leading up to hospital discharge? At present, psychiatry lacks objective tests that could inform this and other clinically challenging–and potentially costly– decisions. Establishing valid objective markers of psychiatric disease processes is especially challenging compared with the development of biomarkers in other 5elds. One key challenge is lack of available data from psychiatrically ill patients during key periods in their care trajectory, which the present project seeks to address. A second major challenge, also addressed as a core feature in this project, is the complex, context-dependence of human behavioral expression, which greatly complicates efforts to establish robust, objective measures that re6ect underlying mental health disease processes. This project will address both barriers, introducing a new computational framework, named Context-Adaptive Multimodal Informatics, to identify and evaluate behavioral biomarkers related to discharge-readiness and symptoms in severe mental illness. The project aims to address 5ve fundamental research challenges: (1) Acquire a multimodal psychiatric discharge-planning dataset of 400 inpatients with severe mental illness; (2) Create self-aware linear and neural models to identify multimodal behavioral biomarkers; (3) Develop context-sensitive linear and neural models to contextualize behavioral biomarkers and quantify the in6uence of context on behavior; (4) Build a new adaptive assessment planning framework which creates a personalized patient analysis to rank contexts and modalities for the next assessment session; (5) Assess the trustworthiness and generalizability of our measurements, models, and insights. This research will improve basic understanding of social context and behavioral biomarkers, build objective measures for mental health assessment, and more broadly, pave the way for a restructured care-delivery system in which resources are allocated intelligently to ensure assessments are informative with respect to desired clinical objectives.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	THE MCLEAN HOSPITAL CORPORATION	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	000	4	6/11/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $276,671 )
2024	2024	THE MCLEAN HOSPITAL CORPORATION	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	000	4	2/26/2024	NON-COMPETING CONTINUATION	$249,004
2024	2024	THE MCLEAN HOSPITAL CORPORATION	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	002	4	6/17/2024	NON-COMPETING CONTINUATION	$27,667
2024	2024	THE MCLEAN HOSPITAL CORPORATION	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	001	4	4/2/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $276,671

Issue Date FY: 2023 ( Subtotal = $253,397 )
2023	2023	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	000	3	3/1/2023	NON-COMPETING CONTINUATION	$253,397
														Subtotal = $253,397

Issue Date FY: 2022 ( Subtotal = $284,235 )
2022	2022	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	001	2	6/21/2022	NON-COMPETING CONTINUATION	$28,426
2022	2022	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	000	2	2/15/2022	NON-COMPETING CONTINUATION	$255,809
														Subtotal = $284,235

Issue Date FY: 2021 ( Subtotal = $346,542 )
2021	2021	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	001	1	5/12/2021	NEW	$0
2021	2021	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	000	1	4/13/2021	NEW	$346,542
														Subtotal = $346,542

Grand Total All Awards = $1,160,845

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SCH: INT: Collaborative Research: Context-Adaptive Multimodal Informatics for Psychiatric Discharge Planning

Award Number: R01MH125740

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/15/2021

PERIOD OF PERFORMANCE END DATE: 02/28/2025

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