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MULTIREGIONAL ELECTRICAL ENCODING OF SOCIAL AGGRESSION

Award Number: R01MH125430
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/15/2021
PERIOD OF PERFORMANCE END DATE: 08/31/2026
AWARD TERMINATION DATE: 05/01/2025

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MULTIREGIONAL ELECTRICAL ENCODING OF SOCIAL AGGRESSION - MULTIREGIONAL ELECTRICAL ENCODING OF SOCIAL AGGRESSION Critical developments in neuroscience have included technologies for sequencing individual brain cells, progress towards completing a full mesoscale brain cell atlas in mice, new tools for monitoring and manipulating the activity of brain cells, refined imaging techniques for developing structural and functional connectome atlases in humans, and new objective measures for characterizing behavior across species. Nevertheless, a critical gap that has yet to be addressed is the development of a model that would allow this emerging catalog of cellular information to be linked to the broad functional networks that encode emotional behavior in mammals. This gap exists in part because 1) technologies that measure, monitor, and decode mesoscale activity throughout the depth of the brain during free behavior in mammalian model species have yet to be implemented in conjunction with cellular activity can be monitored and manipulated, and 2) theoretical frameworks that link cellular activity to mesoscale network activity and that generalize across subjects on a mouse-by-mouse basis have yet to be developed. Our multi-disciplinary team has built a suite of tools for studying how brain dynamics encode complex brain states. These include advanced techniques to measure and monitor brain dynamics in vivo concurrently for months across many regions located throughout the depth of the brain at high spatiotemporal resolution in freely-behaving mice, machine-learning analytic approaches that build individual circuit activity measures into composite networks, behavioral manipulations that can be used to induce brain states related to emotions, viral methods that probe the relationship between cellular changes and the expression of brain-wide neural dynamics, and closed-loop stimulation tools that can potentially test the causality of brain network-states in mediating emotion. By integrating this suite of tools in a single framework, we intend to create a model that will catalogue how the brain generates aggression. Critically, we believe that this model framework will be broadly applicable to other emotional brain states as well.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	000	5	1/27/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $484,578 )
2025	2025	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	002	5	3/28/2025	NON-COMPETING CONTINUATION	$411,891
2025	2025	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	005	5	5/1/2025	NON-COMPETING CONTINUATION	$0
2025	2025	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	006	5	9/23/2025	NON-COMPETING CONTINUATION	$72,687
2025	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	001	4	12/3/2024	SUPPLEMENT FOR EXPANSION	$0
2025	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	000	4	12/3/2024	SUPPLEMENT FOR EXPANSION	$0
2025	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	004	4	5/1/2025	TERMINATION	$0
2025	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	003	4	5/1/2025	TERMINATION	$0
														Subtotal = $484,578

Issue Date FY: 2024 ( Subtotal = $681,500 )
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	003	4	8/14/2024	NON-COMPETING CONTINUATION	$50,800
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	002	4	3/1/2024	SUPPLEMENT FOR EXPANSION	$94,280
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	000	4	2/27/2024	NON-COMPETING CONTINUATION	$457,195
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	001	4	3/1/2024	SUPPLEMENT FOR EXPANSION	$79,225
														Subtotal = $681,500

Issue Date FY: 2023 ( Subtotal = $640,030 )
2023	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	000	3	3/14/2023	NON-COMPETING CONTINUATION	$513,442
2023	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	002	3	8/26/2023	SUPPLEMENT FOR EXPANSION	$63,294
2023	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	001	3	8/23/2023	SUPPLEMENT FOR EXPANSION	$63,294
														Subtotal = $640,030

Issue Date FY: 2022 ( Subtotal = $444,691 )
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Mental Health Research Grants	001	2	3/3/2022	NON-COMPETING CONTINUATION	$439,549
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Mental Health Research Grants	003	2	6/21/2022	NON-COMPETING CONTINUATION	$48,843
2022	2021	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Mental Health Research Grants	002	1	3/14/2022	NEW	-$8,160
2022	2021	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Mental Health Research Grants	000	1	2/28/2022	NEW	-$35,541
														Subtotal = $444,691

Issue Date FY: 2021 ( Subtotal = $608,910 )
2021	2021	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Mental Health Research Grants	000	1	4/8/2021	NEW	$608,910
														Subtotal = $608,910

Grand Total All Awards = $2,859,709

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MULTIREGIONAL ELECTRICAL ENCODING OF SOCIAL AGGRESSION

Award Number: R01MH125430

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/15/2021

PERIOD OF PERFORMANCE END DATE: 08/31/2026

AWARD TERMINATION DATE: 05/01/2025

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