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Next-generation human connectome atlas across the timespan of brain development

Award Number: R01MH125333
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/20/2021
PERIOD OF PERFORMANCE END DATE: 07/31/2025

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Next-generation human connectome atlas across the timespan of brain development - ABSTRACT The formation of a highly efficient and segregated connectome begins during the third trimester and develops throughout infancy, childhood, adolescence, and into adulthood. However, precise and comprehensive delineation of the development of the connectome – elucidating the neural connectome at multiple ages of human development - has been less well studied despite efforts made to assess the lifespan connectome. The human brain connectome is fundamentally underlaid by the cell-to-cell connections that comprise the functional circuitry and global network organization. Region-specific disruptions to neural connectivity may underlie neuropsychiatric disorders including schizophrenia and autism spectrum disorder. In this study, we will establish unique next-generation whole-brain connectomic atlas with connectomic data with resolution of isotropic 1mm or submillimeter during human infancy and childhood to gain hitherto unattainable insights into human brain development and neuropsychiatric disease. The developmental connectome atlas can be potentially associated with precise spatiotemporal patterns of gene expression that differentiate brain regions, cell types, and developmental periods. This atlas will be freely disseminated to the public through an integrated web portal.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2022	THE CHILDREN'S HOSPITAL OF PHILADELPHIA	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	000	2	11/26/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	THE CHILDREN'S HOSPITAL OF PHILADELPHIA	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	000	2	8/13/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $226,877 )
2022	2022	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	001	2	8/1/2022	NON-COMPETING CONTINUATION	$226,877
2022	2021	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	000	1	10/26/2021	NEW	$0
														Subtotal = $226,877

Issue Date FY: 2021 ( Subtotal = $229,517 )
2021	2021	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Mental Health Research Grants	000	1	8/19/2021	NEW	$229,517
														Subtotal = $229,517

Grand Total All Awards = $456,394

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Next-generation human connectome atlas across the timespan of brain development

Award Number: R01MH125333

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/20/2021

PERIOD OF PERFORMANCE END DATE: 07/31/2025

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