Saturday, December 13, 2025 12/13/2025

Alignment of cortical development trajectories with emergent dimensional psychopathology and related risk factors among early adolescents in the ABCD Study

Award Number: R01MH124694
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2020
PERIOD OF PERFORMANCE END DATE: 03/31/2025

Group Awards By:

View Award Description

Alignment of cortical development trajectories with emergent dimensional psychopathology and related risk factors among early adolescents in the ABCD Study - Efforts to decipher biological signatures for mental illness now focus increasingly on adolescence, a period of rapid brain development that immediately precedes the peak age of onset for many disorders. Maturation of the cerebral cortex during this time has long been thought to mediate emergence of early symptoms. However, while specific cortical changes have been implicated in a small number of specific syndromes, for the most part, patterns in cortical development that underlie the differentiation of psychopathology remain uncertain. The ongoing Adolescent Brain Cognitive Development (ABCD) study provides an unprecedented opportunity to align emergence of specific patterns of psychopathology with specific changes in cortical maturation. Over the next 5 years, ABCD will obtain annual, standardized measures dimensional psychopathology, and biennial MRI scans, of 11,875 youths across 21 US-based sites, covering age 9 to 16. The proposed studies will leverage this longitudinal design to discover regionally- and temporally-specific features of cortical development that associate with emergence of dimensional psychopathology, and then to relate these patterns to specific profiles of underlying genomic and environmental risk. Analysis of baseline data from age 9-10, included in this application, indicates that psychopathology is in early stages of differentiation, although already strongly related to polygenic risk for child-onset disorders, and to well- established pre- and post-natal environmental insults. Aim 1 of the proposed studies will juxtapose clinical and imaging data from baseline through three follow-up time points, focusing primarily on whether departures from neurotypical age-related cortical thinning trajectories (assessed via intercept, slope, and quadratic indices) associate with emergence of specific dimensions of illness. The precise temporal alignment of clinical and cortical thinning trajectories will take an initial step towards inferring causal relationships, which will be further substantiated through triangulation with genomic (Aim 2) and environmental (Aim 3) risk profiles. Polygenic scoring methods developed by the Psychiatric Genomics Consortium will be used to determine whether cortical maturation trajectories developed in Aim 1 mediate relationships between genomic risk and emergent dimensional psychopathology. Then, using data from hundreds of environmental measures that canvass participants’ daily activities, nutrition, life stressors, socioeconomic status, family dynamics, neighborhood safety, and numerous other factors, we will use novel machine learning methods to develop profiles of exposomic risk factors that predict emergent dimensional psychopathology, and determine whether cortical maturation patterns mediate the relationship between environmental risk profiles and clinical course. By the conclusion of the proposed studies we hope to establish specific cortical signatures that bridge causal factors with emergent psychopathology in adolescence, and that can be leveraged to develop new preventative interventions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $374,123 )
2025	2025	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Mental Health Research Grants	001	6	3/28/2025	COMPETING CONTINUATION	$428,400
2025	2024	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Mental Health Research Grants	000	5	3/28/2025	NON-COMPETING CONTINUATION	$0
2025	2024	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Mental Health Research Grants	002	5	8/6/2025	NON-COMPETING CONTINUATION	-$54,277
														Subtotal = $374,123

Issue Date FY: 2024 ( Subtotal = $420,000 )
2024	2024	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Mental Health Research Grants	000	5	8/24/2024	NON-COMPETING CONTINUATION	$420,000
														Subtotal = $420,000

Issue Date FY: 2023 ( Subtotal = $420,000 )
2023	2023	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Mental Health Research Grants	000	4	8/10/2023	NON-COMPETING CONTINUATION	$420,000
														Subtotal = $420,000

Issue Date FY: 2022 ( Subtotal = $420,000 )
2022	2022	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Mental Health Research Grants	000	3	8/1/2022	NON-COMPETING CONTINUATION	$420,000
														Subtotal = $420,000

Issue Date FY: 2021 ( Subtotal = $420,000 )
2021	2021	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Mental Health Research Grants	000	2	8/20/2021	NON-COMPETING CONTINUATION	$420,000
														Subtotal = $420,000

Issue Date FY: 2020 ( Subtotal = $413,200 )
2020	2020	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Mental Health Research Grants	000	1	9/11/2020	NEW	$413,200
														Subtotal = $413,200

Grand Total All Awards = $2,467,323

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Alignment of cortical development trajectories with emergent dimensional psychopathology and related risk factors among early adolescents in the ABCD Study

Award Number: R01MH124694

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2020

PERIOD OF PERFORMANCE END DATE: 03/31/2025

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer