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Development of Negative Valence Measures

Award Number: R01MH122537
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2021
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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Development of Negative Valence Measures - PROJECT ABSTRACT Research Domain Criteria (RDoC) is a breakthrough framework for understanding the etiology of mental disorders, but it has no clinical traction at present. Of the RDoC units of analysis, self-report measures can be most feasibly implemented in a clinic, but many self-reports for RDoC’s Negative Valence Systems (NVS) constructs have psychometric shortcomings and lack normative data. We seek to develop psychometrically sound, brief, and validated self-report measures (questionnaires and interviews) of each NVS construct with strong normative data. We will investigate linkages of these self-report measures to other RDoC units of analyses (behavior, task performance, and psychophysiology) to identify self-reports that align with NVS dimensions most strongly and specifically. Also, we will fully characterize clinical manifestations of NVS constructs using a comprehensive dimensional system of symptoms, maladaptive traits, and behaviors (Hierarchical Taxonomy of Psychopathology; HiTOP). The direct counterpart of NVS is internalizing psychopathology, which HiTOP describes with high resolution using 36 specific dimensions. Measure development will be carried out in 2 successive phases, each including a sample of (a) 400 outpatients in psychiatric clinics and (b) 600 community-dwellers. Participants will be adults selected to be representative of the US adult population in terms of age, sex, and ethnicity to obtain strong normative data. In Phase 3, we will validate self-report measures against physiology, task performance, and behavior markers of NVS aligned with the RDoC matrix in a new sample of 300 community adults and 300 psychiatric outpatients. We also will study the longitudinal validity of all new measures over a one-year interval. To facilitate rapid and ethnically diverse data collection, three recruitment sites—Buffalo NY, Stony Brook NY, and Dallas/Denton TX—are proposed. The proposed research will provide a comprehensive catalogue of self-reported characteristics linked to NVS. This will produce stronger measures of NVS constructs and a cross-walk to their clinical manifestations, which will enable clinical translation of NVS. The resulting instruments will be normed, reliable, and highly efficient, and thus scalable to mobile monitoring, screening, and self-administration at population level and clinically. The rigorous and systematic linkage between RDoC NVS constructs and HiTOP internalizing dimensions will be the first step to bringing RDoC and HiTOP together into a unified and evidence-based nosology that integrates etiologic and clinical characterizations of patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Mental Health Research Grants	000	4	1/31/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $728,492 )
2024	2024	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Mental Health Research Grants	001	4	7/9/2024	NON-COMPETING CONTINUATION	$72,848
2024	2024	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Mental Health Research Grants	000	4	3/28/2024	NON-COMPETING CONTINUATION	$655,644
														Subtotal = $728,492

Issue Date FY: 2023 ( Subtotal = $803,022 )
2023	2023	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Mental Health Research Grants	001	3	3/29/2023	SUPPLEMENT FOR EXPANSION	$67,808
2023	2023	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Mental Health Research Grants	000	3	3/27/2023	NON-COMPETING CONTINUATION	$735,214
														Subtotal = $803,022

Issue Date FY: 2022 ( Subtotal = $1,138,066 )
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Mental Health Research Grants	001	2	4/8/2022	NON-COMPETING CONTINUATION	$737,653
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Mental Health Research Grants	002	2	4/12/2022	SUPPLEMENT FOR EXPANSION	$67,683
2022	2021	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Mental Health Research Grants	000	1	11/6/2021	NEW	$332,730
														Subtotal = $1,138,066

Issue Date FY: 2021 ( Subtotal = $804,421 )
2021	2021	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Mental Health Research Grants	000	1	11/27/2020	NEW	$804,421
														Subtotal = $804,421

Grand Total All Awards = $3,474,001

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Development of Negative Valence Measures

Award Number: R01MH122537

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2021

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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