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DEVELOPMENTAL MULTIMODAL IMAGING OF NEUROCOGNITIVE DYNAMICS (DEV-MIND)

Award Number: R01MH121101
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/19/2019
PERIOD OF PERFORMANCE END DATE: 11/30/2025

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DEVELOPMENTAL MULTIMODAL IMAGING OF NEUROCOGNITIVE DYNAMICS (DEV-MIND) - Project Summary/Abstract The Research Domain Criteria (RDoC) project initiated a framework for developing research classifications based on functional dimensions emerging from translational research on genes, behaviors, circuits, and other cognitive-biological parameters. Almost a decade later, RDoC has grown into a matrix consisting of functional domains (e.g., cognitive systems), domain-specific constructs (e.g., attention, perception), and units of analysis for measuring each construct (e.g., physiology, behavior, genes, etc.). Numerous studies have contributed to defining each construct in terms of cognitive-biological parameters, and while these efforts have been broadly successful, the dimensional RDoC constructs themselves remain largely unvalidated. This lack of adequate validation is central to RFA-MH-19-242, which requests proposals that “perform unbiased data-driven validation of existing constructs that may involve merging, subdividing, or hierarchically organizing them by integrating data between and within constructs.” Specifically, the RFA calls for studies that use “multiple behavioral tasks and levels of analysis per construct,” “multimodal data fusion … to unbiasedly classify and compare constructs,” and “data-driven definitions of constructs that involve structural and functional data on how brain states, networks, circuit dynamics, and hierarchies in the signals relate to outputs from task-based assays.” The RFA also encourages the use of “accelerated longitudinal designs, with a particular emphasis on development … and cutting-edge computational approaches to classify, predict, and explain developmental trajectories.” The Developmental Multimodal Imaging of Neurocognitive and (Epi)genomic Dynamics (Dev- MIND) Consortium responds to this call with an innovative, large-scale developmental multimodal neuroimaging study that will leverage previously-developed longitudinal pediatric cohorts and data fusion algorithms that this team established through the NSF-supported Dev-Cog project. Specifically, Dev-MIND will evaluate the unitarity and potential hierarchical structure of three constructs within the cognitive systems domain (i.e., attention, cognitive control, and working memory) using a battery of custom cognitive tasks, multimodal imaging, (epi)genomic analysis, an accelerated longitudinal design, and data-driven similarity metrics for construct validation testing. Our neuroimaging approach will include dynamic functional mapping based on magnetoencephalography (MEG), high-resolution volumetric MRI analyses based on multimodal parcellation, and functional MRI (fMRI) for whole-brain dynamic functional connectivity. These neuroimaging and behavioral performance metrics will also be combined with (epi)genetic data to identify covariance between genomic, cognitive, and neural activity patterns. Such data-driven approaches will enable classification and prediction of developmental trajectories per construct, and are central to the goals of computational psychiatry. In sum, this project brings together leading investigative teams, an array of state-of-the-art neuroimaging technology, and cutting-edge analytical methods to perform unbiased, data-driven validation of existing RDoC constructs.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2023	FATHER FLANAGAN'S BOYS' HOME	14100 CRAWFORD ST	BOYS TOWN	NE	68010	DOUGLAS	USA	Mental Health Research Grants	000	6	3/2/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	FATHER FLANAGAN'S BOYS' HOME	14100 CRAWFORD ST	BOYS TOWN	NE	68010	DOUGLAS	USA	Mental Health Research Grants	000	6	6/10/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $1,098,042 )
2023	2023	FATHER FLANAGAN'S BOYS' HOME	14100 CRAWFORD ST	BOYS TOWN	NE	68010	DOUGLAS	USA	Mental Health Research Grants	000	6	5/18/2023	NON-COMPETING CONTINUATION	$1,098,042
														Subtotal = $1,098,042

Issue Date FY: 2022 ( Subtotal = $1,100,829 )
2022	2022	FATHER FLANAGAN'S BOYS' HOME	13603 FLANAGAN BLVD	BOYS TOWN	NE	68010	DOUGLAS	USA	Mental Health Research Grants	000	5	5/19/2022	NON-COMPETING CONTINUATION	$1,100,829
														Subtotal = $1,100,829

Issue Date FY: 2021 ( Subtotal = $1,209,373 )
2021	2021	FATHER FLANAGAN'S BOYS' HOME	13603 FLANAGAN BLVD	BOYS TOWN	NE	68010	DOUGLAS	USA	Mental Health Research Grants	003	4	6/17/2021	NON-COMPETING CONTINUATION	$1,107,080
2021	2021	FATHER FLANAGAN'S BOYS' HOME	13603 FLANAGAN BLVD	BOYS TOWN	NE	68010	DOUGLAS	USA	Mental Health Research Grants	006	4	8/3/2021	NON-COMPETING CONTINUATION	$490,989
2021	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Mental Health Research Grants	005	2	8/3/2021	NON-COMPETING CONTINUATION	-$124,804
2021	2020	FATHER FLANAGAN'S BOYS' HOME	13603 FLANAGAN BLVD	BOYS TOWN	NE	68010	DOUGLAS	USA	Mental Health Research Grants	001	3	3/22/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,064,022
2021	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Mental Health Research Grants	000	2	3/16/2021	NON-COMPETING CONTINUATION	-$962,194
2021	2020	FATHER FLANAGAN'S BOYS' HOME	13603 FLANAGAN BLVD	BOYS TOWN	NE	68010	DOUGLAS	USA	Mental Health Research Grants	002	3	4/26/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$465
2021	2019	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Mental Health Research Grants	004	1	8/3/2021	NEW	-$366,185
														Subtotal = $1,209,373

Issue Date FY: 2020 ( Subtotal = $1,086,998 )
2020	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Mental Health Research Grants	000	2	7/7/2020	NON-COMPETING CONTINUATION	$1,086,998
														Subtotal = $1,086,998

Issue Date FY: 2019 ( Subtotal = $1,285,534 )
2019	2019	UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Mental Health Research Grants	000	1	8/19/2019	NEW	$1,285,534
														Subtotal = $1,285,534

Grand Total All Awards = $5,780,776

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DEVELOPMENTAL MULTIMODAL IMAGING OF NEUROCOGNITIVE DYNAMICS (DEV-MIND)

Award Number: R01MH121101

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/19/2019

PERIOD OF PERFORMANCE END DATE: 11/30/2025

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