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Longitudinal neuroprotectiveeffects of periconceptional folic acid supplements in help-seeking youth with psychiatric symptomsand healthy controls

Award Number: R01MH120402
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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The prenatal environment contributes substantially to risk for serious mental illnesses that can emerge decades after birth. As such, prenatal life may be a propitious time to intervene in ways that reduce risk. Indeed, replicated, robust evidence from recent public health studies associates early prenatal exposure to folic acid with an approximately 50% reduction in autism risk. Further, our recent work associated increased fetal exposure to population-wide folic acid fortification of grain products with specific changes in brain development, characterized by delayed thinning of the cerebral cortex during adolescence and associated reduction in risk for psychosis symptoms. These changes were most pronounced in regions subserving frontoparietal control and limbic networks, which have been broadly implicated across categories of psychiatric illness, and specifically linked to variation in blood folate levels in healthy adults and patients with schizophrenia by our group. These findings are unprecedented, and of potentially substantial


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $991,176 )
2024	2024	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Mental Health Research Grants	000	5	5/21/2024	NON-COMPETING CONTINUATION	$991,176
														Subtotal = $991,176

Issue Date FY: 2023 ( Subtotal = $991,176 )
2023	2023	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Mental Health Research Grants	000	4	5/31/2023	NON-COMPETING CONTINUATION	$745,823
2023	2023	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Mental Health Research Grants	001	4	9/8/2023	SUPPLEMENT FOR EXPANSION	$245,353
														Subtotal = $991,176

Issue Date FY: 2022 ( Subtotal = $760,586 )
2022	2022	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Mental Health Research Grants	000	3	6/1/2022	NON-COMPETING CONTINUATION	$760,586
														Subtotal = $760,586

Issue Date FY: 2021 ( Subtotal = $770,960 )
2021	2021	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Mental Health Research Grants	000	2	6/1/2021	NON-COMPETING CONTINUATION	$770,960
														Subtotal = $770,960

Issue Date FY: 2020 ( Subtotal = $825,937 )
2020	2020	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Mental Health Research Grants	000	1	7/29/2020	NEW	$825,937
														Subtotal = $825,937

Grand Total All Awards = $4,339,835

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Longitudinal neuroprotectiveeffects of periconceptional folic acid supplements in help-seeking youth with psychiatric symptomsand healthy controls

Award Number: R01MH120402

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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