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Integrative Brain Network-Based Analysis for Heterogeneous and Multimodal

Award Number: R01MH120299
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/26/2021
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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Integrative Brain Network-Based Analysis for Heterogeneous and Multimodal - PROJECT SUMMARY This proposal develops state of the art approaches for addressing challenging questions related to the neurobiological mechanisms affecting clinical outcomes of interest in the presence of heterogeneity represented by underlying disease sub-categories and variability in symptoms and other relevant variables across individuals. We focus on developing integrative approaches for brain connectome based analyses, which combines the multi- modal imaging (e.g. fMRI and diffusion MRI) of brain function and structure, clinical and behavioral measures, while accounting for heterogeneity across samples. Our goals involve important questions in neuroscience which have received limited or no attention so far, such as estimating dynamic brain connectivity while incorporating brain anatomical structure, and subsequently examining which dynamic functional connections drive the clinical outcome, accounting for heterogeneity in terms of disease sub-categories when predicting the clinical outcome based on brain measurements which lie on an underlying brain network, and investigating differences in shapes of white matter fiber bundles which drive the clinical outcome. To address such challenging goals, we develop state-of-the-art statistical approaches which incorporate significant innovations and rely on multi-modal neuroimaging data and uses biologically informed priors which yield meaningful solutions. The motivating dataset is the Grady Trauma Project, which contains neuroimaging, behavioral, and clinical data on subjects who were exposed to trauma and developed some degree of PTSD. We will test our approaches on an external PTSD validation dataset from the ENIGMA-PTSD-PGC consortium. Our methodology development will include proposing novel approaches for (a) the joint modeling of multiple graphical models using network-valued regression; (b) using brain anatomical knowledge to inform the estimation of dynamic connectivity and subsequently using the dynamic functional connections to predict the clinical outcome of interest; (c) developing novel approaches for the joint estimation of multiple regression models corresponding to varying subgroups while incorporating network information characterizing the covariates, and (d) developing Bayesian approaches for 3- dimensional shape estimation for fiber tracts in the brain using anatomically informed priors, and subsequently using the shapes of the estimated fiber bundles to predict the clinical outcomes of interest. We also develop a robust strategy for the validation of the proposed methods and we also provide an outline for developing software and sharing them openly with researchers and interested parties. This application addresses several clinical significant questions in neuroimaging research which have not been explored before due to the lack of state of the art statistical methodology, and is expected to make important methodological, scientific, clinical and translational contributions. .


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2023	THE UNIVERISTY OF TEXAS M.D. ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Mental Health Research Grants	000	5	11/21/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $400,191 )
2023	2023	UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER, THE	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Mental Health Research Grants	001	5	6/26/2023	NON-COMPETING CONTINUATION	$400,191
2023	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Mental Health Research Grants	000	2	11/23/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $400,191

Issue Date FY: 2022 ( Subtotal = $400,191 )
2022	2022	UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER, THE	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Mental Health Research Grants	002	4	7/27/2022	NON-COMPETING CONTINUATION	$400,191
2022	2021	UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER, THE	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Mental Health Research Grants	001	3	2/22/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$286,405
2022	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Mental Health Research Grants	000	2	2/22/2022	NON-COMPETING CONTINUATION	-$286,405
														Subtotal = $400,191

Issue Date FY: 2021 ( Subtotal = $395,071 )
2021	2021	UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER, THE	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Mental Health Research Grants	001	3	7/27/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$395,071
2021	2021	UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER, THE	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Mental Health Research Grants	002	3	8/13/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2021	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Mental Health Research Grants	003	2	8/24/2021	NON-COMPETING CONTINUATION	$0
2021	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Mental Health Research Grants	000	2	7/26/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $395,071

Issue Date FY: 2020 ( Subtotal = $407,395 )
2020	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Mental Health Research Grants	000	2	7/23/2020	NON-COMPETING CONTINUATION	$407,395
														Subtotal = $407,395

Issue Date FY: 2019 ( Subtotal = $427,790 )
2019	2019	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Mental Health Research Grants	000	1	8/26/2019	NEW	$427,790
2019	2019	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Mental Health Research Grants	001	1	9/24/2019	NEW	$0
														Subtotal = $427,790

Grand Total All Awards = $2,030,638

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Integrative Brain Network-Based Analysis for Heterogeneous and Multimodal

Award Number: R01MH120299

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/26/2021

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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