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THE PROGRESSIVE ELEVATION OF SPONTANEOUS CORTICAL ACTIVITY IN HAND (PESCAH) PROJECT

Award Number: R01MH116782
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/15/2021
PERIOD OF PERFORMANCE END DATE: 10/31/2024

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THE PROGRESSIVE ELEVATION OF SPONTANEOUS CORTICAL ACTIVITY IN HAND (PESCAH) PROJECT - Project Summary/Abstract Although HIV-infected patients in the western world have a life expectancy near that of the general population, they are at a significantly elevated risk of developing HIV-associated neurocognitive disorders (HAND). Such disorders are the most common neurological complication of HIV disease, with prevalence estimates ranging from 35-70% of all HIV-infected patients, and research targeting such comorbidities has been identified as a top priority by the Office of AIDS Research (NOT-OD-15-137). While the mechanisms that underlie HAND are not well understood, numerous human neuroimaging studies have examined the brain regions that may be involved, and overall these studies have been largely successful in identifying the critical hubs and large-scale networks. However, many questions remain regarding basic circuit dysfunction within these brain regions, and consequently there is a clear and common need to further investigate the key physiological parameters that may underlie the development and progression of HAND, especially in the context of aging. It is well known that human cortical neurons exhibit spontaneous firing in the absence of incoming exogenous and endogenous input. Across a neuronal population, these discharges summate with local dendritic currents and synaptic potentials to produce cortical rhythmic activity, which is often referred to as “spontaneous activity.” Such spontaneous rhythms are ubiquitous throughout the human brain, but their role in modulating cognition is only beginning to be understood. Recently, we used magnetoencephalography (MEG) to show that the strength of spontaneous activity directly affects neural oscillatory activity in the same cortical area, and in-turn modulates real time task performance in controls and HIV-infected adults. Additionally, we have shown that spontaneous activity in multiple brain regions increases with advancing age, that this increase is deleterious to performance, and that these effects are accentuated in patients with HAND. In fact, our preliminary data suggests that the level of spontaneous activity in specific brain regions may distinguish age-matched HIV-infected patients with and without HAND. In this project, we will quantify the trajectory of age-related elevations in spontaneous cortical activity in a large group of HIV-infected adults and demographically-matched controls. We will then evaluate how the strength of such spontaneous activity affects local neural oscillations and real time cognitive performance. Based on extensive preliminary data, we hypothesize that spontaneous activity will increase with age in both groups, and that the slope of this increase will be steeper in HIV-infected adults relative to controls, and further accentuated in those with HAND. Importantly, we also hypothesize that these increases will be associated with proportional changes in the strength of the neural oscillations underlying cognition, and behavioral performance indices such as accuracy and reaction time. Finally, in Aim 3, we will utilize deep learning methods to classify our sample into groups based on the neurophysiological metrics derived from MEG, with the gold standard being their overall neuropsychological profile.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2022	FATHER FLANAGAN'S BOYS' HOME	14100 CRAWFORD ST	BOYS TOWN	NE	68010	DOUGLAS	USA	Mental Health Research Grants	000	5	3/20/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	FATHER FLANAGAN'S BOYS' HOME	14100 CRAWFORD ST	BOYS TOWN	NE	68010	DOUGLAS	USA	Mental Health Research Grants	000	5	1/10/2024	NON-COMPETING CONTINUATION	$0
2024	2022	FATHER FLANAGAN'S BOYS' HOME	14100 CRAWFORD ST	BOYS TOWN	NE	68010	DOUGLAS	USA	Mental Health Research Grants	001	5	1/10/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $897,142 )
2022	2022	FATHER FLANAGAN'S BOYS' HOME	13603 FLANAGAN BLVD	BOYS TOWN	NE	68010	DOUGLAS	USA	Mental Health Research Grants	001	5	5/16/2022	NON-COMPETING CONTINUATION	$49,206
2022	2022	FATHER FLANAGAN'S BOYS' HOME	13603 FLANAGAN BLVD	BOYS TOWN	NE	68010	DOUGLAS	USA	Mental Health Research Grants	000	5	1/7/2022	NON-COMPETING CONTINUATION	$442,836
2022	2022	FATHER FLANAGAN'S BOYS' HOME	13603 FLANAGAN BLVD	BOYS TOWN	NE	68010	DOUGLAS	USA	Mental Health Research Grants	002	5	6/9/2022	SUPPLEMENT FOR EXPANSION	$405,100
														Subtotal = $897,142

Issue Date FY: 2021 ( Subtotal = $518,570 )
2021	2021	FATHER FLANAGAN'S BOYS' HOME	13603 FLANAGAN BLVD	BOYS TOWN	NE	68010	DOUGLAS	USA	Mental Health Research Grants	001	4	3/11/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$518,570
2021	2021	FATHER FLANAGAN'S BOYS' HOME	13603 FLANAGAN BLVD	BOYS TOWN	NE	68010	DOUGLAS	USA	Mental Health Research Grants	004	4	8/3/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$544,456
2021	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Mental Health Research Grants	000	3	3/10/2021	NON-COMPETING CONTINUATION	$0
2021	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Mental Health Research Grants	003	3	8/3/2021	NON-COMPETING CONTINUATION	-$528,024
2021	2019	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Mental Health Research Grants	002	2	8/3/2021	NON-COMPETING CONTINUATION	-$16,432
														Subtotal = $518,570

Issue Date FY: 2020 ( Subtotal = $528,024 )
2020	2020	UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Mental Health Research Grants	000	3	2/1/2020	NON-COMPETING CONTINUATION	$528,024
														Subtotal = $528,024

Issue Date FY: 2019 ( Subtotal = $525,896 )
2019	2019	UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Mental Health Research Grants	001	2	1/21/2019	NON-COMPETING CONTINUATION	$525,896
2019	2018	UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Mental Health Research Grants	000	1	10/29/2018	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $525,896

Issue Date FY: 2018 ( Subtotal = $903,600 )
2018	2018	UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Mental Health Research Grants	000	1	3/6/2018	NEW	$522,350
2018	2018	UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Mental Health Research Grants	001	1	9/5/2018	SUPPLEMENT FOR EXPANSION	$381,250
														Subtotal = $903,600

Grand Total All Awards = $3,373,232

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THE PROGRESSIVE ELEVATION OF SPONTANEOUS CORTICAL ACTIVITY IN HAND (PESCAH) PROJECT

Award Number: R01MH116782

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/15/2021

PERIOD OF PERFORMANCE END DATE: 10/31/2024

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