Monday, June 30, 2025 6/30/2025

Alpha oscillations and working memory deficits in ADHD: A multimodal imaging investigation

Award Number: R01MH116268
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/30/2023
PERIOD OF PERFORMANCE END DATE: 10/31/2024

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Alpha oscillations and working memory deficits in ADHD: A multimodal imaging investigation - Project Summary High prevalence rates of attention deficit hyperactivity disorder (ADHD) (5-11% of children 4-17 years), combined with its high societal cost, strong persistence and pernicious effects on quality of life, warrant continued efforts to understand its underlying neural mechanisms. Underscoring this need is the increasing recognition that ADHD is clinically and mechanistically heterogeneous, and that this likely degrades the reliability of putative biomarkers of ADHD. Novel, focused studies that aim to reduce such heterogeneity are needed. In this project, we aim to define a robust, relatively unexplored putative biomarker of visual attention deficits, alpha range (8-12Hz) event-related decrease (ERD), which strongly indexes working memory (WM) deficits in ADHD. Using cutting-edge, concurrent EEG-fMRI recordings, we propose to measure event-related alpha ERD and its associated brain activation and network connectivity during WM encoding. The concurrent recordings allow us to directly test if fluctuations in engagement of attention mechanisms captured by the alpha ERD neurophysiological measures predict fluctuations in WM neural processes. Using this methodology, we aim to: (a) identify neural mechanisms underlying alpha ERD deficits and WM performance in ADHD, and (b) define the clinical features of alpha ERD deficits in ADHD, including its effect on real life outcomes such as academic achievement. Unique to this project, we will sample participants who were previously tested in two large ADHD-EEG studies, recruiting them for a longitudinal follow-up experimental session if they are currently in adolescence (14-18 years). By doing so we aim to (c) characterize the developmental trajectory of attention deficits as captured by alpha ERD in ADHD, as well its impact on the trajectory of clinical and real-life outcomes. The adolescent sample will provide new insight into neural and neurophysiological characteristics of ADHD during this developmental period. The outcome of this research is a clearly defined neural mechanism, alpha ERD, that can be targeted in treatment of WM deficits in ADHD, or in other neuropsychiatric disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$1,357 )
2025	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	000	5	3/20/2025	NON-COMPETING CONTINUATION	-$1,147
2025	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	001	5	3/20/2025	SUPPLEMENT FOR EXPANSION	-$209
														Subtotal = -$1,357

Issue Date FY: 2023 ( Subtotal = $800,822 )
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	002	5	9/1/2023	SUPPLEMENT FOR EXPANSION	$123,477
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	001	5	2/21/2023	NON-COMPETING CONTINUATION	$67,734
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	000	5	11/1/2022	NON-COMPETING CONTINUATION	$609,611
														Subtotal = $800,822

Issue Date FY: 2022 ( Subtotal = $711,455 )
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	001	4	5/16/2022	NON-COMPETING CONTINUATION	$71,144
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	000	4	10/25/2021	NON-COMPETING CONTINUATION	$640,311
														Subtotal = $711,455

Issue Date FY: 2021 ( Subtotal = $707,797 )
2021	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	001	3	4/13/2021	NON-COMPETING CONTINUATION	$70,779
2021	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	3	11/18/2020	NON-COMPETING CONTINUATION	$637,018
														Subtotal = $707,797

Issue Date FY: 2020 ( Subtotal = $682,993 )
2020	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	002	2	8/17/2020	SUPPLEMENT FOR EXPANSION	$48,338
2020	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	2	11/6/2019	NON-COMPETING CONTINUATION	$571,189
2020	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	001	2	2/3/2020	NON-COMPETING CONTINUATION	$63,466
														Subtotal = $682,993

Issue Date FY: 2019 ( Subtotal = $603,658 )
2019	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	001	1	9/24/2019	NEW	$0
2019	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	1	11/6/2018	NEW	$603,658
														Subtotal = $603,658

Grand Total All Awards = $3,505,368

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Alpha oscillations and working memory deficits in ADHD: A multimodal imaging investigation

Award Number: R01MH116268

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/30/2023

PERIOD OF PERFORMANCE END DATE: 10/31/2024

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