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Next generation in-vivo diffusion imaging at submillimeter resolution

Award Number: R01MH116173
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 11/01/2020
PERIOD OF PERFORMANCE END DATE: 06/30/2029

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Next generation in-vivo diffusion imaging at submillimeter resolution - PROJECT SUMMARY/ABSTRACT Diffusion MRI (dMRI), with its sensitivity to neurological changes, has contributed immensely to our understanding of the white matter structure at large-to-medium spatial scales, and more recently towards smaller structures, particularly in the cortical and subcortical regions, as submillimeter dMRI is starting to become more feasible. Nonetheless, further increase in resolution is required to move dMRI to the mesoscopic scale (100- 500µm), to improve sensitivity to small but important brain microstructural features and improve capability to e.g. detect highly-localized tissue abnormalities such as focal cortical dysplasia and silent acute microinfarcts, as well as enable study of brain connectivity across laminar structures and delineate functionally important small sub-cortical gray matter structures. In this proposal, we aim to develop imaging technologies to allow mesoscale dMRI and extend our development to enable mesoscale joint diffusion-relaxometry MRI with rich information, to improve tractography’s robustness and enhance capability to extract detailed microstructural information. Mesoscale dMRI and diffusion-relaxometry MRI will enhance the capability of many current clinical and neuroscientific investigations and open doors to entirely new ones, facilitating new discoveries to deepen our understanding of the human brain in both its healthy and diseased states. In the previous funding cycle, we developed the gSlider-SMS technology to allow 700-800µm dMRI to be acquired in a short 20-minute timeframe and shared it across 26 research institutes world-wide, where it is being used to investigate numerous neuroscientific questions and neurological disorders, including aging, epilepsy, acute micro-infarcts, and deep-brain stimulation planning. For this renewal, we propose to create technologies to allow 300-500µm whole-brain dMRI in 20-30 minutes, with fast reconstruction, suitable for wide-adoption. We will then expand our development to create a joint T2-dMRI acquisition for fiber-specific microstructure imaging and improved fiber tracking capability at the mesoscopic scale. Lastly, we will also create a highly efficient joint T1-T2-dMRI acquisition, to rapidly collect large multidimensional data and provide diffusion-relaxation correlation spectroscopic map per imaging voxel for detailed microstructural investigation. The multitude of imaging technologies that we will develop will enable creation of new richer datasets that will have a significant and lasting impact on the neuroscientific study of the human brain and many clinical applications. Optimized protocols will be developed for high-end clinical 3T MRIs for wide deployment, and on high-performance head-only 3T MRIs to enable neuroscientific explorations at the limit.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Mental Health Research Grants	000	7	1/13/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $756,795 )
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Mental Health Research Grants	000	7	8/22/2025	NON-COMPETING CONTINUATION	$756,795
														Subtotal = $756,795

Issue Date FY: 2024 ( Subtotal = $795,377 )
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Mental Health Research Grants	001	6	9/17/2024	COMPETING CONTINUATION	$795,377
2024	2022	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Mental Health Research Grants	000	5	6/3/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $795,377

Issue Date FY: 2022 ( Subtotal = $725,271 )
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Mental Health Research Grants	000	5	2/9/2022	NON-COMPETING CONTINUATION	$652,742
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Mental Health Research Grants	001	5	5/13/2022	NON-COMPETING CONTINUATION	$72,529
														Subtotal = $725,271

Issue Date FY: 2021 ( Subtotal = $761,808 )
2021	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Mental Health Research Grants	003	4	9/22/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$352,814
2021	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Mental Health Research Grants	001	4	3/26/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$761,808
2021	2020	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Mental Health Research Grants	000	3	3/26/2021	NON-COMPETING CONTINUATION	$0
2021	2020	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Mental Health Research Grants	002	3	9/22/2021	NON-COMPETING CONTINUATION	-$352,814
														Subtotal = $761,808

Issue Date FY: 2020 ( Subtotal = $760,423 )
2020	2020	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Mental Health Research Grants	000	3	1/24/2020	NON-COMPETING CONTINUATION	$760,423
														Subtotal = $760,423

Issue Date FY: 2019 ( Subtotal = $769,923 )
2019	2019	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Mental Health Research Grants	000	2	1/21/2019	NON-COMPETING CONTINUATION	$769,923
														Subtotal = $769,923

Issue Date FY: 2018 ( Subtotal = $843,728 )
2018	2018	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Mental Health Research Grants	000	1	2/27/2018	NEW	$843,728
														Subtotal = $843,728

Grand Total All Awards = $5,413,325

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Next generation in-vivo diffusion imaging at submillimeter resolution

Award Number: R01MH116173

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 11/01/2020

PERIOD OF PERFORMANCE END DATE: 06/30/2029

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