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Models of Neuromodulatory Circuits in Drosophila

Award Number: R01MH114017
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2018
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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Models of Neuromodulatory Circuits in Drosophila - ABSTRACT We propose to use a model circuit in Drosophila to study aminergic neuromodulation. The relatively small number of presynaptic cells combined with easy access to both pre- and post-synaptic sites will allow us to quantify the activity of each aminergic neuron, their functional relationships to post-synaptic targets and how their activities are coordinated. Recently developed molecular genetic tools will allow us to map all of the relevant receptors for the first time. New methods of preparing the tissue will allow us to identify the function of both direct and indirect regulatory pathways. Using RNAi transgenes as well as classical mutations we will define the function of all of the aminergic and glutamatergic receptors in the circuit and how they interact. Preliminary Data have uncovered unexpected complexities in this relatively simple circuit that will be relevant to a variety of other more complex circuits less amenable to the detailed analysis we propose here.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	000	5	6/7/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $410,692 )
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	000	5	8/17/2022	NON-COMPETING CONTINUATION	$410,692
														Subtotal = $410,692

Issue Date FY: 2021 ( Subtotal = $410,692 )
2021	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	000	4	6/23/2021	NON-COMPETING CONTINUATION	$410,692
														Subtotal = $410,692

Issue Date FY: 2020 ( Subtotal = $410,692 )
2020	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	3	6/24/2020	NON-COMPETING CONTINUATION	$410,692
														Subtotal = $410,692

Issue Date FY: 2019 ( Subtotal = $423,992 )
2019	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	2	6/19/2019	NON-COMPETING CONTINUATION	$423,992
														Subtotal = $423,992

Issue Date FY: 2018 ( Subtotal = $452,307 )
2018	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	1	8/30/2018	NEW	$452,307
														Subtotal = $452,307

Grand Total All Awards = $2,108,375

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Models of Neuromodulatory Circuits in Drosophila

Award Number: R01MH114017

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2018

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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