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Genome-wide association studies of anxiety spectrum phenotypes: Furthering the PGC Anxiety Disorders Working Group

Award Number: R01MH113665
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2017
PERIOD OF PERFORMANCE END DATE: 05/31/2029

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Genome-wide association studies of anxiety spectrum phenotypes: Furthering the PGC Anxiety Disorders Working Group - Anxiety disorders such as generalized anxiety disorder, panic disorder, and phobias are highly prevalent in the population and carry a significant burden of distress and impairment. Only a moderate proportion of patients with anxiety disorders respond adequately to current treatment interventions, and anxiety disorders are relatively understudied compared to other psychiatric syndromes. Exploring their genetic determinants will help elucidate their causes and guide research for prevention and new treatments. In our first funding period, we built the foundation for conducting sufficiently powered genome-wide association study (GWAS) meta-analyses for the anxiety disorders through the newly established Anxiety Disorders Working Group of the Psychiatric Genetics Consortium (PGC-ANX). We assembled data from 36 European ancestry cohorts totaling 122K composite ANX cases and 730K controls. We performed case-control SNP- and gene-based analyses and identified genome-wide significant associations in 58 independent SNPs and 91 genes, respectively. The purpose of this current application is to expand the sample size, identify susceptibility loci for each anxiety disorder, and extend those results beyond European ancestry individuals. We will apply these results to refine the prediction of clinical risk for anxiety. This study will provide new insights into genetic mechanisms underlying the development of anxiety disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $577,249 )
2025	2025	TEXAS A & M UNIVERSITY SYSTEM HEALTH SCIENCE CENTER	6003 TAMU	COLLEGE STATION	TX	77843	BRAZOS	USA	Mental Health Research Grants	000	5	8/1/2025	COMPETING CONTINUATION	$577,249
														Subtotal = $577,249

Issue Date FY: 2024 ( Subtotal = -$12,742 )
2024	2020	TEXAS A & M UNIVERSITY SYSTEM HEALTH SCIENCE CENTER	6003 TAMU	COLLEGE STATION	TX	77843	BRAZOS	USA	Mental Health Research Grants	000	4	2/2/2024	NON-COMPETING CONTINUATION	-$12,742
														Subtotal = -$12,742

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	TEXAS A&M UNIVERSITY SYSTEM, THE	8441 RIVERSIDE PARKWAY BLDG 1 STE 3100	BRYAN	TX	77807	BRAZOS	USA	Mental Health Research Grants	000	4	7/5/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $312,656 )
2020	2020	TEXAS A&M UNIVERSITY SYSTEM, THE	8441 RIVERSIDE PARKWAY BLDG 1 STE 3100	BRYAN	TX	77807	BRAZOS	USA	Mental Health Research Grants	005	4	6/9/2020	NON-COMPETING CONTINUATION	$352,721
2020	2019	TEXAS A&M UNIVERSITY SYSTEM, THE	8441 RIVERSIDE PARKWAY BLDG 1 STE 3100	BRYAN	TX	77807	BRAZOS	USA	Mental Health Research Grants	000	3	1/18/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$40,065
2020	2019	TEXAS A&M UNIVERSITY SYSTEM, THE	8441 RIVERSIDE PARKWAY BLDG 1 STE 3100	BRYAN	TX	77807	BRAZOS	USA	Mental Health Research Grants	004	3	2/5/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$434,152
2020	2018	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Mental Health Research Grants	003	2	2/5/2020	SUPPLEMENT FOR EXPANSION	-$45,638
2020	2018	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Mental Health Research Grants	002	2	2/5/2020	NON-COMPETING CONTINUATION	-$381,064
2020	2017	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Mental Health Research Grants	001	1	2/5/2020	NEW	-$7,450
														Subtotal = $312,656

Issue Date FY: 2019 ( Subtotal = $417,699 )
2019	2019	TEXAS A&M UNIVERSITY SYSTEM, THE	8441 RIVERSIDE PARKWAY BLDG 1 STE 3100	BRYAN	TX	77807	BRAZOS	USA	Mental Health Research Grants	001	3	9/11/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$417,699
2019	2018	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Mental Health Research Grants	000	2	9/11/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $417,699

Issue Date FY: 2018 ( Subtotal = $426,702 )
2018	2018	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Mental Health Research Grants	000	2	5/31/2018	NON-COMPETING CONTINUATION	$381,064
2018	2018	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Mental Health Research Grants	001	2	8/17/2018	SUPPLEMENT FOR EXPANSION	$45,638
														Subtotal = $426,702

Issue Date FY: 2017 ( Subtotal = $381,191 )
2017	2017	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Mental Health Research Grants	000	1	8/28/2017	NEW	$381,191
														Subtotal = $381,191

Grand Total All Awards = $2,102,755

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Genome-wide association studies of anxiety spectrum phenotypes: Furthering the PGC Anxiety Disorders Working Group

Award Number: R01MH113665

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2017

PERIOD OF PERFORMANCE END DATE: 05/31/2029

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